{"id":"W3036259241","doi":"10.1016/j.jconrel.2020.06.017","title":"Blockade of CTLA-4 increases anti-tumor response inducing potential of dendritic cell vaccine","year":2020,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":94,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Tabriz University of Medical Sciences; Iran National Science Foundation","keywords":"Cancer research; Tumor microenvironment; Priming (agriculture); Cytotoxic T cell; CTLA-4; Dendritic cell; Immunotherapy; Chemistry; T cell; Cancer immunotherapy; Tumor antigen; Immune system; Immunology; Medicine; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001026285,0.0002386327,0.001502977,0.0003368535,0.0000964373,0.00001099003,0.000388353,0.0001861808,0.0005406561],"category_scores_gemma":[0.002423211,0.0001836982,0.0006359083,0.0002406943,0.0001306877,0.0001431236,0.0000566873,0.0005525417,0.00001748994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002353205,"about_ca_system_score_gemma":0.0005024651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005116162,"about_ca_topic_score_gemma":4.306026e-7,"domain_scores_codex":[0.9963453,0.001475193,0.001592562,0.0001576727,0.000131003,0.0002982961],"domain_scores_gemma":[0.9964166,0.001155534,0.001638941,0.0002354006,0.0004839616,0.00006958607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1532318,0.0004842382,0.0002665898,0.00006160772,0.0007084155,0.0001794859,0.0002826045,0.0001401613,0.8433105,0.000008615018,0.0006113523,0.0007146241],"study_design_scores_gemma":[0.0520777,0.003292718,0.006173233,0.0003108739,0.0005831341,0.0007215834,0.0005107368,0.00006586947,0.9342574,0.00001685227,0.001792574,0.000197297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9581797,0.0399524,0.0003649426,0.0008221992,0.0003317923,0.0002624215,0.00002438921,0.00001107599,0.0000510502],"genre_scores_gemma":[0.9983788,0.0007923975,0.00009125498,0.0003190703,0.00009315525,0.000002717873,0.000002776119,0.00002635941,0.0002935438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1011541,"threshold_uncertainty_score":0.7490996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006328018006606722,"score_gpt":0.2163023751877403,"score_spread":0.2099743571811335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}