{"id":"W3036355166","doi":"10.1093/cid/ciaa809","title":"Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy","year":2020,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; National Institute on Aging; National Institute of Neurological Disorders and Stroke; amfAR, The Foundation for AIDS Research","keywords":"Provirus; Virology; DNA; Virus; Human immunodeficiency virus (HIV); Lentivirus; Antiretroviral therapy; Medicine; Long terminal repeat; Viral disease; Viral load; Biology; Immunology; Genome; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005872924,0.0003153702,0.000302338,0.0006853574,0.0001256985,0.0006367806,0.0002263174,0.0002475343,0.001435582],"category_scores_gemma":[0.001524618,0.0001790997,0.0001009363,0.0003871752,0.0003578432,0.0005335459,0.0001927861,0.0008368448,0.000235866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001585341,"about_ca_system_score_gemma":0.0001976127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004499444,"about_ca_topic_score_gemma":0.0005780017,"domain_scores_codex":[0.9995549,0.00009998951,0.00004178447,0.00006780659,0.0001711468,0.0000643516],"domain_scores_gemma":[0.9990753,0.0002926827,0.000216024,0.0001016872,0.0001704496,0.0001438797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001748058,0.000459867,0.1380831,0.0001149368,0.00008475928,0.0002074347,0.000416461,0.0006415202,0.8088815,0.0005595724,0.0003224805,0.04848033],"study_design_scores_gemma":[0.00005978082,0.004483897,0.3285671,0.00005999797,0.0001305218,0.002650877,0.0003065269,0.005712288,0.6543187,0.0006890938,0.002977958,0.00004339945],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904652,0.002279204,0.004630664,0.00004645954,0.00001933516,0.00004542071,0.0005441221,0.00007581379,0.001893728],"genre_scores_gemma":[0.9948041,0.0004417049,0.002742594,0.00003909344,0.00001897317,0.00002944182,0.0004971795,0.000008779628,0.001418093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001435582,"threshold_uncertainty_score":0.004802465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03471513022407643,"score_gpt":0.3209491754616246,"score_spread":0.2862340452375481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}