{"id":"W3036372528","doi":"10.1080/23723556.2020.1768819","title":"TDG is a novel tumor suppressor of liver malignancies","year":2020,"lang":"en","type":"article","venue":"Molecular & Cellular Oncology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Farnesoid X receptor; DNA demethylation; Cancer research; Demethylation; Suppressor; Bile acid; Small heterodimer partner; Hepatocellular carcinoma; Gene; Biology; DNA glycosylase; Tumor suppressor gene; Nuclear receptor; Cell biology; Chemistry; Carcinogenesis; DNA repair; Transcription factor; Biochemistry; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007744817,0.0003164662,0.0002102651,0.0003886666,0.0001705559,0.0003049155,0.0002397127,0.0002925405,0.0009320391],"category_scores_gemma":[0.00008866676,0.00006847084,0.0001453371,0.0002523368,0.0002121097,0.00009431806,0.0002608534,0.000315359,0.0003560314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002847823,"about_ca_system_score_gemma":0.0001556132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002916118,"about_ca_topic_score_gemma":0.0003644771,"domain_scores_codex":[0.9999495,0.000004427329,0.000003389314,0.00001564928,0.00001813452,0.000009038938],"domain_scores_gemma":[0.9999541,0.000006065255,0.00001343214,0.000003924817,0.000004082176,0.00001838214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003270712,0.00004043922,0.00355626,0.0001129327,0.00003010904,0.00413582,0.00002924524,0.0003167801,0.9676583,0.001809059,0.0009484313,0.02103547],"study_design_scores_gemma":[0.0001741777,0.0005837579,0.02968979,0.00002442238,0.0001208454,0.02001192,0.00007893601,0.003841883,0.8044302,0.001374202,0.1396342,0.00003565884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9552933,0.02140711,0.01440328,0.0008388,0.0007219762,0.00005931425,0.001476465,0.001153113,0.00464661],"genre_scores_gemma":[0.9905482,0.002838808,0.001869806,0.0001547343,0.00006102961,0.00001543965,0.001118641,0.00002675573,0.003366582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009320391,"threshold_uncertainty_score":0.003117979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634313320340603,"score_gpt":0.2363882385267491,"score_spread":0.220045105323343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}