{"id":"W3036372528","doi":"10.1080/23723556.2020.1768819","title":"TDG is a novel tumor suppressor of liver malignancies","year":2020,"lang":"en","type":"article","venue":"Molecular & Cellular Oncology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Farnesoid X receptor; DNA demethylation; Cancer research; Demethylation; Suppressor; Bile acid; Small heterodimer partner; Hepatocellular carcinoma; Gene; Biology; DNA glycosylase; Tumor suppressor gene; Nuclear receptor; Cell biology; Chemistry; Carcinogenesis; DNA repair; Transcription factor; Biochemistry; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001745915,0.0002821173,0.0004407773,0.0000506258,0.00004503483,0.00001248293,0.0004853027,0.0002943274,0.0002167632],"category_scores_gemma":[0.0001475749,0.000298427,0.0002945081,0.0001610186,0.0001717399,0.000004681244,0.0004131406,0.0001568311,0.00006817066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002589316,"about_ca_system_score_gemma":0.0002151106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002707676,"about_ca_topic_score_gemma":0.000005119161,"domain_scores_codex":[0.9981433,0.0001254222,0.0004039859,0.0006530089,0.0002520366,0.0004222398],"domain_scores_gemma":[0.9988523,0.00001504947,0.0002172428,0.0005432232,0.0001622489,0.000209902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001472381,0.000184941,0.00005252767,0.00007382135,0.0001269255,0.0002411995,0.0002605099,0.00003991533,0.9959357,0.0006392826,0.002020487,0.0002773893],"study_design_scores_gemma":[0.0009189926,0.001284273,0.0000405133,0.000009957773,0.00007465819,0.00004901469,0.0000817351,0.0004108345,0.8957757,0.00005673664,0.1010278,0.0002698085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9466057,0.001789482,0.04827616,0.0009252583,0.0001746188,0.0004060222,0.0000723254,0.00003961664,0.001710846],"genre_scores_gemma":[0.9825905,0.00003435846,0.01139092,0.005371231,0.000150952,0.00004164208,0.00008588103,0.00006622009,0.0002683284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1001601,"threshold_uncertainty_score":0.9999468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634313320340603,"score_gpt":0.2363882385267491,"score_spread":0.220045105323343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}