{"id":"W3036427315","doi":"10.1158/1078-0432.ccr-20-0103","title":"Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE)","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Alexandra Hospital; BC Cancer Agency; Foothills Medical Centre; Canadian Centre for Applied Research in Cancer Control; Vancouver General Hospital; Alberta Health Services; University of British Columbia","funders":"National Cancer Institute; Cancer Council Tasmania; Cancer Council Victoria; Horizon 2020 Framework Programme; Peter MacCallum Foundation; BC Cancer Foundation; University College London Hospitals NHS Foundation Trust; Medical Research and Materiel Command; Eisai; Canada Excellence Research Chairs, Government of Canada; Bundesministerium für Bildung und Forschung; Canada Research Chairs; Canadian Institutes of Health Research; Cancer Institute NSW; Cancer Australia; Mayo Clinic; Ovarian Cancer Action; Michael Smith Health Research BC; National Health and Medical Research Council; AstraZeneca; Invitae; Daiichi-Sankyo; MacroGenics; National Institute for Health and Care Research; Clovis Oncology; Cancer Research UK; University College London; Cancer Council NSW; Ovarian Cancer Australia; National Institutes of Health; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Celgene; Carrick Therapeutics; Ignyta; U.S. Department of Defense; Eli Lilly and Company; Cancer Council South Australia; Deutsches Krebsforschungszentrum; Pfizer; European Commission; Breast Cancer Research Foundation; American Oil Chemists' Society; National Center for Advancing Translational Sciences; Medical Research Council; Teva Pharmaceutical Industries; American Cancer Society","keywords":"Serous fluid; Ovarian carcinoma; Serous carcinoma; Oncology; Ovarian cancer; Serous ovarian cancer; Gene expression; Gene expression profiling; Clinical trial; Internal medicine; Gene; Medicine; Bioinformatics; Biology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006464295,0.00009659314,0.000338134,0.00003905433,0.00006228209,0.00000853208,0.0001456256,0.0001421511,0.0001216079],"category_scores_gemma":[0.0003187456,0.00006234417,0.00007581049,0.0003020137,0.0002060981,0.00002693827,0.0001969378,0.0003922524,0.000003488037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008763888,"about_ca_system_score_gemma":0.0007492327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000301702,"about_ca_topic_score_gemma":0.00001301173,"domain_scores_codex":[0.9980475,0.0002437586,0.0005046022,0.0003477258,0.000659147,0.0001972656],"domain_scores_gemma":[0.9988644,0.0001874544,0.0001301571,0.0003281556,0.0002737983,0.0002160167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001493972,0.0006755313,0.919686,0.0005967536,0.0002462045,0.00004502366,0.001011016,0.00002250731,0.06152954,0.0004383852,0.001415747,0.01283938],"study_design_scores_gemma":[0.001968695,0.0004296596,0.4364824,0.0001611509,0.00004930768,0.000001183382,0.00003337798,0.00002362635,0.5594809,0.00006321083,0.001263046,0.00004348362],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905172,0.001005286,0.00005284252,0.007383245,0.00010844,0.0008119141,0.00002457258,0.000008783866,0.00008774707],"genre_scores_gemma":[0.9970385,0.0002517744,0.002140752,0.0002204716,0.0001589857,0.0001257327,0.00001185975,0.00001791176,0.00003403889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4979514,"threshold_uncertainty_score":0.2542321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1808203520512986,"score_gpt":0.4301660530588109,"score_spread":0.2493457010075122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}