{"id":"W3036427315","doi":"10.1158/1078-0432.ccr-20-0103","title":"Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE)","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Alexandra Hospital; BC Cancer Agency; Foothills Medical Centre; Canadian Centre for Applied Research in Cancer Control; Vancouver General Hospital; Alberta Health Services; University of British Columbia","funders":"National Cancer Institute; Cancer Council Tasmania; Cancer Council Victoria; Horizon 2020 Framework Programme; Peter MacCallum Foundation; BC Cancer Foundation; University College London Hospitals NHS Foundation Trust; Medical Research and Materiel Command; Eisai; Canada Excellence Research Chairs, Government of Canada; Bundesministerium für Bildung und Forschung; Canada Research Chairs; Canadian Institutes of Health Research; Cancer Institute NSW; Cancer Australia; Mayo Clinic; Ovarian Cancer Action; Michael Smith Health Research BC; National Health and Medical Research Council; AstraZeneca; Invitae; Daiichi-Sankyo; MacroGenics; National Institute for Health and Care Research; Clovis Oncology; Cancer Research UK; University College London; Cancer Council NSW; Ovarian Cancer Australia; National Institutes of Health; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Celgene; Carrick Therapeutics; Ignyta; U.S. Department of Defense; Eli Lilly and Company; Cancer Council South Australia; Deutsches Krebsforschungszentrum; Pfizer; European Commission; Breast Cancer Research Foundation; American Oil Chemists' Society; National Center for Advancing Translational Sciences; Medical Research Council; Teva Pharmaceutical Industries; American Cancer Society","keywords":"Serous fluid; Ovarian carcinoma; Serous carcinoma; Oncology; Ovarian cancer; Serous ovarian cancer; Gene expression; Gene expression profiling; Clinical trial; Internal medicine; Gene; Medicine; Bioinformatics; Biology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002243595,0.0004650452,0.0005578559,0.0007026601,0.0002557283,0.0006596969,0.0004606268,0.00032806,0.0007317359],"category_scores_gemma":[0.003834435,0.0001671852,0.0005094534,0.0004497122,0.0003103287,0.0002260217,0.0005350646,0.0006479239,0.000323707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004799123,"about_ca_system_score_gemma":0.001033626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002775486,"about_ca_topic_score_gemma":0.003668708,"domain_scores_codex":[0.9991702,0.0002445697,0.00007107455,0.0001983126,0.0002493637,0.00006638784],"domain_scores_gemma":[0.998051,0.0009406719,0.0003019788,0.0002264881,0.0003935799,0.00008624965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009101984,0.0002664666,0.8604468,0.0001180098,0.0002674437,0.00008659002,0.0000761565,0.03854477,0.03958594,0.0004057421,0.0009856276,0.05830629],"study_design_scores_gemma":[0.0001332309,0.001098402,0.5134199,0.00005783648,0.0002364799,0.0004535663,0.0001394765,0.4168687,0.06422471,0.001378995,0.001949486,0.00003921089],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9652617,0.0002010372,0.03150127,0.0001409511,0.00001330648,0.00008914193,0.002044671,0.0001633165,0.0005845153],"genre_scores_gemma":[0.9773661,0.00005355717,0.01898508,0.00005301581,0.000009796405,0.00008710648,0.00317494,0.00001744587,0.0002529369],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002775486,"threshold_uncertainty_score":0.01186538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1808203520512986,"score_gpt":0.4301660530588109,"score_spread":0.2493457010075122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}