{"id":"W3036453600","doi":"10.1128/aac.00402-20","title":"Antifungal Susceptibility of Clinical Yeast Isolates from a Large Canadian Reference Laboratory and Application of Whole-Genome Sequence Analysis To Elucidate Mechanisms of Acquired Resistance","year":2020,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Toronto; London Health Sciences Centre; Public Health Ontario","funders":"","keywords":"Caspofungin; Biology; Microbiology; Candida tropicalis; Candida glabrata; Anidulafungin; Echinocandin; Micafungin; Fluconazole; Candida parapsilosis; Corpus albicans; Candida albicans; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006896734,0.0004291841,0.0003456777,0.002223101,0.001495616,0.001026414,0.0007490105,0.0003038154,0.001198445],"category_scores_gemma":[0.001953925,0.0001714657,0.0003399474,0.003554425,0.0004722528,0.0001713479,0.0004717233,0.000340678,0.0001660133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009597016,"about_ca_system_score_gemma":0.0106825,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9380397,"about_ca_topic_score_gemma":0.9587626,"domain_scores_codex":[0.9989007,0.00005568952,0.00007784565,0.000197412,0.0005704967,0.0001978902],"domain_scores_gemma":[0.9984028,0.00009353444,0.0002023008,0.00006040967,0.001113304,0.0001276758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000513443,0.0001744835,0.8460576,0.0004209589,0.0001570237,0.001292966,0.002896321,0.001287505,0.09680743,0.0006518115,0.003861973,0.04587852],"study_design_scores_gemma":[0.00001641022,0.00008517439,0.9839848,0.00005698968,0.0000713499,0.0006461722,0.001074279,0.0008262321,0.005838323,0.00003560624,0.007346807,0.00001787674],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807481,0.001823074,0.001820641,0.00032708,0.00002305386,0.0001833929,0.01086042,0.00006346585,0.004150827],"genre_scores_gemma":[0.9859126,0.001138222,0.004075831,0.0002443515,0.00001336289,0.0000492728,0.007159919,0.0000198259,0.001386487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06196028,"threshold_uncertainty_score":0.1246503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03107488119877565,"score_gpt":0.3133171213453174,"score_spread":0.2822422401465417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}