{"id":"W3036464240","doi":"10.1126/sciadv.abb1250","title":"Allosteric pluripotency as revealed by protein kinase A","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Allosteric regulation; Computational biology; Kinase; Protein kinase A; Allosteric enzyme; Cell biology; Biology; Enzyme; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000844942,0.0001151454,0.0001186879,0.00007367525,0.0001559305,0.0003099426,0.0002029688,0.0002133397,0.0009099233],"category_scores_gemma":[0.0001949508,0.000118118,0.0001167479,0.0000780898,0.0003669569,0.0003385983,0.0002940589,0.0004112911,0.000132209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002410449,"about_ca_system_score_gemma":0.0001305696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002631922,"about_ca_topic_score_gemma":0.0002458083,"domain_scores_codex":[0.9999604,0.000006181695,0.000001713077,0.00001244763,0.00001140861,0.000007814775],"domain_scores_gemma":[0.9999635,0.0000106559,0.000007727092,0.000006353805,0.000002726134,0.000009010336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001488513,0.00003741064,0.001128136,0.0000534262,0.00001926668,0.0001461978,0.00007307288,0.01072628,0.9545238,0.0259499,0.0002741905,0.006919533],"study_design_scores_gemma":[0.0001253866,0.0004509668,0.008401687,0.00002228343,0.00005263406,0.0004504896,0.0001460606,0.3449586,0.5850637,0.05123663,0.009025819,0.00006567979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856895,0.0004584766,0.01003222,0.0002011312,0.00002709806,0.000005798513,0.00006134613,0.0001208133,0.003403605],"genre_scores_gemma":[0.9986766,0.0002237314,0.0007140333,0.00004282745,0.000002865347,0.000004503686,0.00002652222,0.000008570982,0.0003003978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009099233,"threshold_uncertainty_score":0.003044009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007970205911920401,"score_gpt":0.24927440117479,"score_spread":0.2413041952628696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}