{"id":"W3036466860","doi":"10.1016/j.jid.2020.03.616","title":"606 Small molecule blockade of T-type calcium channels by DX416 inhibits itch and reduces corresponding inflammation in acute and chronic itch mouse models","year":2020,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemokine; Immune system; Inflammation; Pharmacology; Voltage-dependent calcium channel; Immunology; Cytokine; Medicine; Calcium channel; Monocyte; Calcium; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001616628,0.0006161929,0.0006063603,0.0004161863,0.0002548747,0.0003948464,0.0003155626,0.0006770797,0.004478201],"category_scores_gemma":[0.0001302353,0.000190379,0.0004060157,0.0002392149,0.0004806569,0.0003608227,0.0001579844,0.001682575,0.0009015203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002088275,"about_ca_system_score_gemma":0.0003698635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005629097,"about_ca_topic_score_gemma":0.0009934343,"domain_scores_codex":[0.9997798,0.00002483975,0.00002232627,0.00003586265,0.00004649052,0.00009075704],"domain_scores_gemma":[0.9998566,0.00001452884,0.00003076778,0.00001182226,0.00001052877,0.00007575096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002458502,0.0005592176,0.0002905815,0.0001103229,0.00002419164,0.0001371422,0.00002385441,0.0001297108,0.9911019,0.0002293668,0.000462217,0.004472919],"study_design_scores_gemma":[0.001332394,0.006897246,0.006230878,0.00002330114,0.0000793834,0.0004960456,0.0001084847,0.00133256,0.9790351,0.0001896351,0.004254261,0.00002069152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920066,0.001525294,0.001343411,0.0004924759,0.0002632731,0.00007720421,0.0008309605,0.000241794,0.003219086],"genre_scores_gemma":[0.9878083,0.00209311,0.001573199,0.0002011032,0.00007973655,0.0001229889,0.0009042037,0.00003490925,0.007182497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004478201,"threshold_uncertainty_score":0.01498103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03787886704190774,"score_gpt":0.2786018826631276,"score_spread":0.2407230156212198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}