{"id":"W3036473409","doi":"10.1038/s41591-020-0933-1","title":"Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes","year":2020,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":292,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; BC Children's Hospital; University Health Network; University of British Columbia","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Cell-free fetal DNA; Receiver operating characteristic; Renal cell carcinoma; Urine; DNA; Cell; Cancer research; Cancer; Molecular biology; Oncology; Biology; Medicine; Internal medicine; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007578707,0.0001124691,0.0001696531,0.00003435435,0.00003010393,0.000003294216,0.0001082084,0.0001981832,0.00001034925],"category_scores_gemma":[0.0002113947,0.00009568178,0.00003247416,0.00009132238,0.00007510829,0.000001458366,0.0001088046,0.0001782174,2.990845e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009327286,"about_ca_system_score_gemma":0.00003944321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004442051,"about_ca_topic_score_gemma":0.0000276272,"domain_scores_codex":[0.9993758,0.00001713342,0.0001557118,0.0002243517,0.000113779,0.0001132286],"domain_scores_gemma":[0.9995279,0.00002713146,0.00008816496,0.00018683,0.00006773834,0.0001021812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001179049,0.00001229311,0.0006093836,0.0000745607,0.00001040615,0.000005230057,0.00008310947,0.00003361838,0.9972563,0.000008621833,0.001006922,0.000781687],"study_design_scores_gemma":[0.001556797,0.000698638,0.001320911,0.00001033455,0.00006552773,0.000009573529,0.00006844004,0.000417285,0.981999,0.00002713495,0.01373151,0.00009489331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871431,0.01064649,0.0006565323,0.0006594312,0.0001845692,0.00009226733,0.0000256207,0.00000414951,0.000587834],"genre_scores_gemma":[0.9976016,0.0003909933,0.0005493939,0.0005998078,0.0007746657,0.000001527069,0.00002801256,0.00001493109,0.00003904953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01525731,"threshold_uncertainty_score":0.390179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007422775867031604,"score_gpt":0.2276796300769031,"score_spread":0.2202568542098715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}