{"id":"W3036501203","doi":"10.1038/s41375-020-0929-3","title":"Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia","year":2020,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Neuroblastoma RAS viral oncogene homolog; Chronic myelomonocytic leukemia; Cancer research; Azacitidine; Trametinib; In vivo; Medicine; Transplantation; Leukemia; Biology; Immunology; Bone marrow; Cancer; Myelodysplastic syndromes; MAPK/ERK pathway; Internal medicine; KRAS; Gene; Gene expression; Signal transduction; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024605,0.000467033,0.0004564784,0.0002781614,0.0001388896,0.0003275496,0.0002390394,0.000313865,0.001125052],"category_scores_gemma":[0.0001023704,0.0001172865,0.0002334185,0.0001611132,0.0001409833,0.0002032912,0.0001316799,0.0006536935,0.0002265806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002929466,"about_ca_system_score_gemma":0.0002681823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004509389,"about_ca_topic_score_gemma":0.00106511,"domain_scores_codex":[0.9998661,0.00003272685,0.00001182567,0.00003052201,0.00003358663,0.00002517353],"domain_scores_gemma":[0.9999373,0.00001114753,0.00001602955,0.00001024353,0.000006312322,0.00001900315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003035805,0.0004009949,0.0002968568,0.00003944837,0.000009889235,0.00005497282,0.00001660936,0.0003019701,0.994675,0.0001151113,0.0001044401,0.003681164],"study_design_scores_gemma":[0.0001476711,0.005365217,0.002615979,0.000006888693,0.00005719635,0.0004222522,0.00001868187,0.001839819,0.9855821,0.00004618179,0.003892031,0.000006004811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933188,0.001277704,0.003387971,0.000125469,0.00004105732,0.0001423982,0.0005938508,0.0001227241,0.0009899732],"genre_scores_gemma":[0.9923005,0.001058645,0.004306952,0.00003934358,0.000009655102,0.0001033246,0.0008248963,0.00001727777,0.001339345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001125052,"threshold_uncertainty_score":0.003763616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02038921142134412,"score_gpt":0.2670072797449849,"score_spread":0.2466180683236408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}