{"id":"W3036549350","doi":"10.1002/path.5493","title":"<scp>SMARCB1</scp> loss induces druggable cyclin <scp>D1</scp> deficiency via upregulation of <scp><i>MIR17HG</i></scp> in atypical teratoid rhabdoid tumors","year":2020,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Montreal Children's Hospital; McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"SMARCB1; Cyclin D1; Cancer research; Atypical teratoid rhabdoid tumor; Cyclin B; Downregulation and upregulation; microRNA; Cyclin D; Cyclin B1; Cell cycle; Biology; Epigenetics; Cancer; Genetics; Gene; Chromatin remodeling; Cyclin-dependent kinase 1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132281,0.0002128344,0.0002128748,0.0002389394,0.0001447596,0.0002743027,0.000154993,0.0002508778,0.001317255],"category_scores_gemma":[0.00009717459,0.000152786,0.000219754,0.0001278311,0.0002519152,0.0001230977,0.0001422935,0.0005429418,0.000612011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002873534,"about_ca_system_score_gemma":0.0002590202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004806183,"about_ca_topic_score_gemma":0.0006294937,"domain_scores_codex":[0.9998647,0.00002333327,0.00001834647,0.00002584549,0.00004103107,0.00002674106],"domain_scores_gemma":[0.9999011,0.00001759535,0.00003198759,0.00001202556,0.000006718694,0.00003067276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001106715,0.0000345964,0.0004367451,0.00002675201,0.000008266459,0.0001819921,0.000008760229,0.00007636092,0.9976473,0.0001015161,0.0001051057,0.001261714],"study_design_scores_gemma":[0.00002860475,0.0002940899,0.006642713,0.000004232267,0.00001834383,0.001212783,0.00002529894,0.001209566,0.9868007,0.00005646284,0.003703446,0.000003766949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927334,0.00181482,0.002261531,0.0001798122,0.00003594516,0.0000344641,0.0005530735,0.0001813661,0.002205701],"genre_scores_gemma":[0.9956861,0.0006786896,0.001232036,0.00005967382,0.000007307231,0.00003297941,0.0006011091,0.00003098436,0.00167107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001317255,"threshold_uncertainty_score":0.004406691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01239036841472703,"score_gpt":0.2448801678855944,"score_spread":0.2324897994708674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}