{"id":"W3036584797","doi":"10.3389/fmicb.2020.01399","title":"The Inhibition of Antibiotic Production in Streptomyces coelicolor Over-Expressing the TetR Regulator SCO3201 IS Correlated With Changes in the Lipidome of the Strain","year":2020,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Science and Technology Planning Project of Guangdong Province; Basic and Applied Basic Research Foundation of Guangdong Province; Centre National de la Recherche Scientifique; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China; Agence Nationale de la Recherche","keywords":"TetR; Streptomyces coelicolor; Operon; Biology; Biochemistry; Gene; Regulator gene; Streptomyces; Response regulator; Biosynthesis; Regulator; Transcriptome; Strain (injury); Plasmid; Gene expression; Bacteria; Genetics; Repressor; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001029866,0.000581493,0.0004822329,0.0002919752,0.0001184336,0.0003511804,0.0001666498,0.0002202067,0.0008978354],"category_scores_gemma":[0.0001824974,0.0001386414,0.0002849162,0.000363502,0.0001889958,0.0001207334,0.0003410495,0.0004893242,0.0003996885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002285908,"about_ca_system_score_gemma":0.0002453891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001529933,"about_ca_topic_score_gemma":0.00136605,"domain_scores_codex":[0.9996985,0.00003656666,0.00003435172,0.0000566241,0.0001055889,0.00006844653],"domain_scores_gemma":[0.9997302,0.0000471224,0.00007330808,0.00003042144,0.00002931072,0.00008966275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003845008,0.00001118017,0.00012048,0.000009574368,0.00000159431,0.0000237638,0.000005907143,0.0000150951,0.9994893,0.00000937856,0.000007459043,0.0002678948],"study_design_scores_gemma":[0.00000698953,0.000258927,0.01017748,0.000004883882,0.00000805746,0.0001429897,0.00004686906,0.0004898132,0.9882086,0.00001515667,0.0006347831,0.000005553911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965283,0.0004068336,0.001164616,0.00007379884,0.000018513,0.00001944594,0.0005777988,0.00008305542,0.001127583],"genre_scores_gemma":[0.9940596,0.0002950116,0.001535625,0.00004381107,0.000007161904,0.00003496832,0.001254102,0.00003819575,0.002731577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001529933,"threshold_uncertainty_score":0.003042042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009735019217208488,"score_gpt":0.2156270373903398,"score_spread":0.2058920181731314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}