{"id":"W3036613347","doi":"10.3389/fimmu.2020.01648","title":"Cytokine Storm in COVID-19—Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":516,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"World Health Organization","keywords":"Cytokine storm; Medicine; Immunology; Macrophage activation syndrome; Intensive care medicine; Cytokine; Pathogenesis; Vasculitis; Sepsis; Cytokine release syndrome; Immune system; Disease; Coronavirus disease 2019 (COVID-19); Immunotherapy; Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002402342,0.0002275591,0.0008347952,0.0001423277,0.0001814518,0.00003556276,0.0001891235,0.0003844422,0.00008064945],"category_scores_gemma":[0.03028621,0.0001590087,0.0001301487,0.0003271247,0.001689609,0.00007771382,0.0003089069,0.001424254,0.00001080208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002433026,"about_ca_system_score_gemma":0.0004942497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009121006,"about_ca_topic_score_gemma":0.00005207827,"domain_scores_codex":[0.9962479,0.00132929,0.000974084,0.0007312169,0.0002425445,0.0004750025],"domain_scores_gemma":[0.9951388,0.003929574,0.0001586595,0.0005105434,0.00006448559,0.0001979386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01249845,0.002845156,0.8016891,0.0005760127,0.001472885,0.002588265,0.007235105,0.0001601489,0.006087597,0.0359525,0.006603739,0.122291],"study_design_scores_gemma":[0.02068462,0.007844715,0.8091823,0.000189748,0.0003398758,0.0002300213,0.01070729,0.006240129,0.0001717728,0.08365673,0.05998601,0.0007667732],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.3493161,0.03205101,0.04417375,0.5679896,0.001100775,0.004740945,0.00003520088,0.0003168296,0.0002757599],"genre_scores_gemma":[0.9489014,0.004970103,0.005658089,0.04007624,0.0000760751,0.0002530844,0.00002290087,0.0000195975,0.00002256449],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5995852,"threshold_uncertainty_score":0.9778821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1228697758327887,"score_gpt":0.3955049253284608,"score_spread":0.2726351494956721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}