{"id":"W3036626624","doi":"10.1158/1557-3265.liqbiop20-pr09","title":"Abstract PR09: Frequency and etiology of ctDNA-positive metastatic prostate cancer with BRCA2, ATM, or CDK12 mutations","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"PTEN; Cancer research; Prostate cancer; Mutation; Cancer; CDKN2A; Germline mutation; Biology; DNA repair; Germline; DNA damage; Somatic cell; Gene; Medicine; Genetics; DNA; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001738626,0.0002834042,0.0002331521,0.001412536,0.0003559579,0.0003553158,0.0006308219,0.0005336499,0.006000279],"category_scores_gemma":[0.001570608,0.0001972512,0.0002328863,0.0008605041,0.0003496252,0.0002594497,0.000411181,0.0004389466,0.0008047278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001559452,"about_ca_system_score_gemma":0.0001734525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001863184,"about_ca_topic_score_gemma":0.001013663,"domain_scores_codex":[0.9996369,0.00005876191,0.00003609798,0.0001300526,0.00008272537,0.00005544139],"domain_scores_gemma":[0.9991663,0.0001594125,0.0003517412,0.00004461411,0.00006667672,0.0002113339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001337258,0.00002169079,0.9946297,0.00001231097,0.00002055002,0.001088042,0.00002896376,0.00003945865,0.001912136,0.00002678357,0.0001735672,0.001913046],"study_design_scores_gemma":[0.000005952922,0.0001164031,0.9842387,0.000004309251,0.00002321092,0.01442301,0.0001055157,0.0002590634,0.0005227274,0.00003429089,0.0002619802,0.000004908045],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981235,0.0003567773,0.000150366,0.00004950535,0.00000611157,0.000007872101,0.0004055501,0.00001743593,0.0008830052],"genre_scores_gemma":[0.9995852,0.00005302173,0.00005536777,0.00001025314,0.000008838354,0.000002733979,0.0001722387,0.000003762675,0.0001085582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006000279,"threshold_uncertainty_score":0.02007294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3145723633926266,"score_gpt":0.5531282130071178,"score_spread":0.2385558496144912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}