{"id":"W3036713033","doi":"10.1016/j.jcf.2020.06.001","title":"Tezacaftor/ivacaftor in people with cystic fibrosis who stopped lumacaftor/ivacaftor due to respiratory adverse events","year":2020,"lang":"en","type":"article","venue":"Journal of Cystic Fibrosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Newcastle upon Tyne Hospitals NHS Foundation Trust; Imperial College London; National Center for Advancing Translational Sciences; Manitoba Beekeepers' Association; National Institute for Health and Care Research; University of Pittsburgh","keywords":"Ivacaftor; Medicine; Cystic fibrosis; Discontinuation; Adverse effect; Placebo; Internal medicine; Cystic fibrosis transmembrane conductance regulator; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001084698,0.0008153337,0.002255055,0.001073689,0.0001916451,0.00007201999,0.0009189855,0.0003213973,0.000616697],"category_scores_gemma":[0.005118989,0.000667289,0.0005290852,0.002421613,0.0001993598,0.0008374522,0.0003346233,0.001410085,0.0002713474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00106026,"about_ca_system_score_gemma":0.001360399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009451815,"about_ca_topic_score_gemma":0.00001595353,"domain_scores_codex":[0.9923026,0.0004547682,0.002141184,0.0009315766,0.002805041,0.001364862],"domain_scores_gemma":[0.9937366,0.001167589,0.0009330225,0.0008120282,0.0009727503,0.002377986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.07595073,0.001753732,0.3255164,0.004558518,0.001165019,0.004847257,0.001762489,0.005687347,0.5353059,0.00009289287,0.03654484,0.006814857],"study_design_scores_gemma":[0.01536822,0.01973427,0.8831088,0.006218007,0.0008168035,0.001083645,0.001584409,0.001145472,0.01225481,0.0001089769,0.05715658,0.001420037],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890329,0.00125731,0.00587604,0.001736691,0.0001139582,0.001450715,0.0001511271,0.00009250495,0.0002887045],"genre_scores_gemma":[0.9481417,0.00003757231,0.04812631,0.001926744,0.001115072,0.00008530547,0.0000167307,0.0001914791,0.0003590692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5575924,"threshold_uncertainty_score":0.9995778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01673131866231859,"score_gpt":0.2904480074773019,"score_spread":0.2737166888149833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}