{"id":"W3036745223","doi":"10.1007/s12015-020-09986-5","title":"Immortalization of Mesenchymal Stromal Cells by TERT Affects Adenosine Metabolism and Impairs their Immunosuppressive Capacity","year":2020,"lang":"en","type":"article","venue":"Stem Cell Reviews and Reports","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Mesenchymal stem cell; Purinergic receptor; Adenosine deaminase; Cell biology; Stromal cell; Extracellular; Biology; Purinergic signalling; Adenosine; Regenerative medicine; Immortalised cell line; Stem cell; Cell; Cancer research; Biochemistry; Adenosine receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007653463,0.0003416394,0.001202547,0.0000680952,0.00009561958,0.00003796486,0.00008102633,0.0001535499,0.000134418],"category_scores_gemma":[0.00007508534,0.0002238479,0.0001853365,0.0002718435,0.0001896395,0.0001329419,0.0001549896,0.0002718771,0.000004035351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002000994,"about_ca_system_score_gemma":0.00007432548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007310121,"about_ca_topic_score_gemma":0.000001735335,"domain_scores_codex":[0.99737,0.000264918,0.0009147939,0.0006153898,0.0004649056,0.000370015],"domain_scores_gemma":[0.9982033,0.00007858587,0.0006684195,0.0004300217,0.0001324396,0.0004872428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008131732,0.0001407323,0.01258324,0.004821749,0.0001069906,0.0003457795,0.001335804,0.00000111587,0.9642078,0.00001665692,0.007939915,0.008418852],"study_design_scores_gemma":[0.001420684,0.001042343,0.01439989,0.001046797,0.0004937906,0.0008361458,0.0004879468,0.0002529621,0.848841,0.00001749366,0.1306384,0.0005225602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8460769,0.1490123,0.0001260769,0.0002690295,0.000155066,0.001958152,0.00002653955,0.00002807068,0.002347809],"genre_scores_gemma":[0.9781899,0.02046686,0.0002229839,0.0001151008,0.0001097785,0.00003967744,0.00004463845,0.0000361923,0.0007748245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.132113,"threshold_uncertainty_score":0.9128254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02657520256714302,"score_gpt":0.2551237610883719,"score_spread":0.2285485585212289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}