{"id":"W3036749792","doi":"10.1016/j.annonc.2020.06.006","title":"HSD3B1 (1245A&gt;C) germline variant and clinical outcomes in metastatic castration-resistant prostate cancer patients treated with abiraterone and enzalutamide: results from two prospective studies","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Abbotsford Veterinary Clinic; Surrey Memorial Hospital; University of British Columbia, Okanagan Campus; Kelowna General Hospital; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Genentech; BC Cancer Foundation; Cilag; Astellas Pharma; Ministerio de Ciencia e Innovación; Instituto de Salud Carlos III; Prostate Cancer Canada; Ipsen; Clovis Oncology; Celgene; BC Cancer Agency; Prostate Cancer Foundation; Movember Foundation; Bristol-Myers Squibb; AstraZeneca; Pfizer; Sanofi; Jane ja Aatos Erkon Säätiö","keywords":"Enzalutamide; Medicine; Prostate cancer; Hazard ratio; Oncology; Internal medicine; Proportional hazards model; Genotype; Androgen deprivation therapy; Confidence interval; Cancer; Androgen receptor; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003405444,0.0002100733,0.0009711063,0.00008643642,0.0000488109,0.00001189085,0.00004565788,0.00006464942,0.000009996204],"category_scores_gemma":[0.0004240538,0.0001296647,0.00004165037,0.0002060249,0.0004334632,0.0001044085,0.00006458228,0.0002131265,0.000001447808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007834811,"about_ca_system_score_gemma":0.0003217774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001230166,"about_ca_topic_score_gemma":0.002392981,"domain_scores_codex":[0.9980603,0.0002051237,0.0007239492,0.0004999166,0.0002271959,0.000283528],"domain_scores_gemma":[0.9984195,0.0005292947,0.0002698132,0.0001284259,0.0004576123,0.0001954015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02460194,0.0008526991,0.9583079,0.0001043376,0.001723917,0.0006375651,0.003998067,0.000009276148,0.0006857595,0.00001893973,0.0002127205,0.008846875],"study_design_scores_gemma":[0.02888964,0.01691219,0.9511508,0.0001652649,0.0003130215,0.000004313641,0.0005709364,0.00009405743,0.00140434,0.0001475783,0.0002069373,0.0001408769],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846609,0.002405082,8.747868e-7,0.01099965,0.00003562409,0.001219235,0.0005753998,0.00001647343,0.00008675564],"genre_scores_gemma":[0.9932035,0.005436854,0.0003703871,0.0005745346,0.00004544322,0.00009310713,0.0001062637,0.00001812737,0.0001517953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01605949,"threshold_uncertainty_score":0.5287572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1704008119239594,"score_gpt":0.4690823410987344,"score_spread":0.298681529174775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}