{"id":"W3036749792","doi":"10.1016/j.annonc.2020.06.006","title":"HSD3B1 (1245A&gt;C) germline variant and clinical outcomes in metastatic castration-resistant prostate cancer patients treated with abiraterone and enzalutamide: results from two prospective studies","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Abbotsford Veterinary Clinic; Surrey Memorial Hospital; University of British Columbia, Okanagan Campus; Kelowna General Hospital; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Genentech; BC Cancer Foundation; Cilag; Astellas Pharma; Ministerio de Ciencia e Innovación; Instituto de Salud Carlos III; Prostate Cancer Canada; Ipsen; Clovis Oncology; Celgene; BC Cancer Agency; Prostate Cancer Foundation; Movember Foundation; Bristol-Myers Squibb; AstraZeneca; Pfizer; Sanofi; Jane ja Aatos Erkon Säätiö","keywords":"Enzalutamide; Medicine; Prostate cancer; Hazard ratio; Oncology; Internal medicine; Proportional hazards model; Genotype; Androgen deprivation therapy; Confidence interval; Cancer; Androgen receptor; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000888672,0.0006294178,0.0006073131,0.0004888747,0.0004243101,0.0009567564,0.0004256457,0.0004827071,0.001215091],"category_scores_gemma":[0.001783801,0.0003890019,0.001131208,0.001326527,0.000577103,0.0003106185,0.0003192952,0.0005352642,0.000161492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004276879,"about_ca_system_score_gemma":0.0004125644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004168773,"about_ca_topic_score_gemma":0.005113392,"domain_scores_codex":[0.9994316,0.0001896045,0.00006656467,0.0001596887,0.00009633737,0.00005617712],"domain_scores_gemma":[0.9982378,0.0003802325,0.0008364457,0.0001570574,0.0001345804,0.000253849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01233974,0.0002016306,0.9785322,0.0001171685,0.002560883,0.0001377133,0.0000979305,0.0001432393,0.001854969,0.00003527654,0.0001525001,0.003826737],"study_design_scores_gemma":[0.0007749687,0.001013344,0.9943089,0.00002001048,0.002465799,0.0003980413,0.00009492829,0.0001354909,0.0003467739,0.00005671996,0.0003676738,0.00001727461],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970837,0.002130533,0.00005876283,0.00003166165,0.00001309227,0.00001131921,0.0004412709,0.000003191583,0.0002264866],"genre_scores_gemma":[0.9988563,0.0004711875,0.0000649533,0.00002825378,0.00001785829,0.000008093755,0.0004451846,0.000002201014,0.0001060147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004168773,"threshold_uncertainty_score":0.008289039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1704008119239594,"score_gpt":0.4690823410987344,"score_spread":0.298681529174775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}