{"id":"W3036756394","doi":"10.18433/jpps30942","title":"In Vitro ADME, Preclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of RBx14255, a Novel Ketolide with Pharmacodynamics Against Multidrug-Resistant Bacterial Pathogens","year":2020,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pharmacokinetics; Telithromycin; Pharmacology; Ketolide; Bioavailability; Pharmacodynamics; In vivo; Potency; Haemophilus influenzae; ADME; Chemistry; Streptococcus pneumoniae; In vitro; Medicine; Antibiotics; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007154823,0.0004028002,0.0004575706,0.0002122991,0.00008734543,0.0003181855,0.0001772413,0.0002966399,0.001005986],"category_scores_gemma":[0.0005889834,0.0002169392,0.000242219,0.0001488135,0.0001840371,0.0001868707,0.0001036704,0.0004870872,0.0003558214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003808475,"about_ca_system_score_gemma":0.00031436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006743033,"about_ca_topic_score_gemma":0.0008735029,"domain_scores_codex":[0.9997379,0.0001090583,0.00001879451,0.00004261099,0.00007132126,0.0000203103],"domain_scores_gemma":[0.9997936,0.00005700259,0.00007991865,0.00002059654,0.00002510291,0.00002369144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005439248,0.0006419203,0.004342469,0.0003394661,0.0001545749,0.0001836715,0.00008799451,0.007696351,0.9473498,0.0002373451,0.0006212743,0.03290582],"study_design_scores_gemma":[0.0009447003,0.04240778,0.03576666,0.00004989918,0.000494671,0.002148107,0.00007579855,0.0281779,0.8811054,0.0001297654,0.008642849,0.00005642914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863253,0.005876189,0.00555759,0.0001474866,0.00003156341,0.0001044517,0.0005664464,0.00008706705,0.00130399],"genre_scores_gemma":[0.9938904,0.001716728,0.002651954,0.00004213042,0.00001462985,0.00004385029,0.0006957655,0.00001136993,0.0009333125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005986,"threshold_uncertainty_score":0.003783882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0893092015756993,"score_gpt":0.3992805358562409,"score_spread":0.3099713342805416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}