{"id":"W3036759197","doi":"10.1038/s41580-020-0255-7","title":"ERK signalling: a master regulator of cell behaviour, life and fate","year":2020,"lang":"en","type":"review","venue":"Nature Reviews Molecular Cell Biology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1202,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; MAPK/ERK pathway; Kinase; Biology; Cell growth; Cell fate determination; Extracellular; Cell; Signal transduction; Intracellular; Protein kinase A; Cell signaling; Regulator; Cell metabolism; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006779174,0.001158703,0.001195714,0.001343168,0.0002215938,0.001446518,0.0008510035,0.001360344,0.003098384],"category_scores_gemma":[0.000569267,0.0003219217,0.000253921,0.001684987,0.0007393989,0.001569181,0.0009154733,0.0025911,0.002652771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009971728,"about_ca_system_score_gemma":0.001273119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000901896,"about_ca_topic_score_gemma":0.002324972,"domain_scores_codex":[0.999842,0.00001780809,0.00001644724,0.0000275142,0.00007254101,0.00002361147],"domain_scores_gemma":[0.9997659,0.00007952331,0.00003187128,0.000007055592,0.00007261868,0.00004306899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001519524,0.00003853077,0.00009641658,0.00696549,0.00005931103,0.0001223771,0.00002941159,0.0005648852,0.004290111,0.005990103,0.05789797,0.9237933],"study_design_scores_gemma":[0.0000259588,0.0000401364,0.0004621004,0.0009878427,0.00005360492,0.0003647911,0.00003226517,0.0001232762,0.000817084,0.002895577,0.9941826,0.00001472599],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001182575,0.9968998,0.000266703,0.0007016849,0.0005488617,0.000004586245,0.00003211714,0.00001431625,0.001413608],"genre_scores_gemma":[0.0007201227,0.9971386,0.0001723497,0.0003625099,0.0003384995,0.000006104544,0.00004520328,0.000002057557,0.00121463],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003098384,"threshold_uncertainty_score":0.01036519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02423147105711939,"score_gpt":0.280338448925497,"score_spread":0.2561069778683777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}