{"id":"W3036780800","doi":"10.1186/s12862-020-01633-4","title":"Evolution and transition of expression trajectory during human brain development","year":2020,"lang":"en","type":"article","venue":"BMC Evolutionary Biology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Diabetes Canada; University of Toronto","funders":"Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Heterochrony; Neoteny; Human brain; Biology; Transcriptome; Rhesus macaque; Lineage (genetic); Macaque; Neuroscience; Brain development; Brain size; Period (music); Human evolution; Evolutionary biology; Ontogeny; Gene; Gene expression; Genetics; Zoology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006761555,0.0001173026,0.0001343184,0.00003725383,0.0001204931,0.000002311048,0.000078571,0.0001735172,0.00001614123],"category_scores_gemma":[0.00002746342,0.0001175244,0.00005139742,0.00005184187,0.0001221628,0.000005014199,0.0000360396,0.00006362199,0.000001718137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001978335,"about_ca_system_score_gemma":0.00007393128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000122709,"about_ca_topic_score_gemma":0.00001668768,"domain_scores_codex":[0.9991673,0.00009505417,0.0002346993,0.0002996534,0.00005414096,0.0001491056],"domain_scores_gemma":[0.9997256,0.00001092667,0.00006209631,0.00009163901,0.00004010323,0.00006961877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002013319,0.00004750568,0.02459337,0.00007400017,0.00001209033,3.884589e-7,0.0001852913,0.0001005902,0.9744502,0.0001169066,0.0001419204,0.00007639024],"study_design_scores_gemma":[0.001549237,0.0005610234,0.3594161,0.00003497272,0.00001356769,0.00001726491,0.0001420005,0.0002932204,0.6351914,0.0001453904,0.002345806,0.0002900393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726595,0.001059122,0.02586461,0.0001183394,0.00005945899,0.0001222569,0.00001922209,0.00001828699,0.00007920202],"genre_scores_gemma":[0.99617,0.00001815302,0.003234911,0.0001024936,0.000171974,0.0000112459,0.0002489261,0.00001135852,0.0000308907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3392588,"threshold_uncertainty_score":0.4792504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01975538542758048,"score_gpt":0.2312887981266179,"score_spread":0.2115334126990374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}