{"id":"W3036816724","doi":"10.1016/j.jacbts.2020.02.004","title":"Mechanisms of Cardiovascular Benefits of Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors","year":2020,"lang":"en","type":"review","venue":"JACC Basic to Translational Science","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":872,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; University of Alberta","funders":"Boehringer Ingelheim; Novo Nordisk; Sanofi; Bayer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; Servier; Amgen","keywords":"Medicine; Empagliflozin; Heart failure; Natriuresis; Internal medicine; Diabetes mellitus; Endocrinology; Cardiology; Oxidative stress; Pharmacology; Blood pressure; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005943,0.0003425702,0.001665091,0.0004458615,0.00006082031,0.00001495733,0.0003650122,0.0001169651,0.0001216615],"category_scores_gemma":[0.00002245596,0.0002687657,0.001082146,0.001363006,0.0002122409,0.0001489713,0.00003177857,0.0001393959,0.00004431666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007713564,"about_ca_system_score_gemma":0.0006023264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002091021,"about_ca_topic_score_gemma":0.000002777466,"domain_scores_codex":[0.9966831,0.00003091676,0.00074879,0.0006469221,0.00157354,0.0003167569],"domain_scores_gemma":[0.9988558,0.000058788,0.0002053808,0.0004513044,0.0001613604,0.0002673869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000193519,0.000152664,0.00001994706,0.005198226,0.0007275229,0.00001196774,0.000144309,0.0000550205,0.00007610373,0.004381254,0.00006751045,0.9891461],"study_design_scores_gemma":[0.0007934461,0.0003544191,0.0007928287,0.005409719,0.004586594,0.000006015513,0.00001186035,0.00001275454,0.002120071,0.0001832295,0.9854061,0.0003229667],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002249014,0.9923477,0.001859922,0.0002948706,0.0002593868,0.002113667,0.0002474153,0.00003895759,0.002613136],"genre_scores_gemma":[0.01106691,0.9820077,0.006040917,0.0001356643,0.000163577,0.0001392249,0.0002647591,0.00005569145,0.0001255499],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9888232,"threshold_uncertainty_score":0.9999765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0328152155289663,"score_gpt":0.2903976320520634,"score_spread":0.2575824165230971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}