{"id":"W3036843612","doi":"10.1097/cji.0000000000000325","title":"A Phase I, Dose Escalation, Single Dose Trial of Oral Attenuated Salmonella typhimurium Containing Human IL-2 in Patients With Metastatic Gastrointestinal Cancers","year":2020,"lang":"en","type":"article","venue":"Journal of Immunotherapy","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Toxicity; Medicine; Flow cytometry; Adverse effect; Progressive disease; Regimen; Pharmacology; Immunology; Salmonella; Cancer; Internal medicine; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009011948,0.001521217,0.001724213,0.0004614057,0.0004049637,0.0007193335,0.0005695291,0.00102675,0.001579162],"category_scores_gemma":[0.0006245667,0.0004953385,0.0008747457,0.0003040977,0.000847336,0.0005807312,0.0002671018,0.002155103,0.0003521484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006854038,"about_ca_system_score_gemma":0.001048931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005586916,"about_ca_topic_score_gemma":0.001440617,"domain_scores_codex":[0.9997266,0.0001162775,0.00001609811,0.00004160165,0.00002812722,0.00007129007],"domain_scores_gemma":[0.9996276,0.00007458016,0.00007742296,0.00004949562,0.00002620603,0.0001446591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4648613,0.1320308,0.01115042,0.00136611,0.001245139,0.00063929,0.0007298692,0.006605303,0.2357079,0.0007018115,0.00443414,0.140528],"study_design_scores_gemma":[0.185821,0.7861701,0.01053437,0.00002904466,0.0002641283,0.0003036396,0.00006347701,0.001424548,0.01332853,0.0001744344,0.001858886,0.00002790423],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969046,0.0005810737,0.0003467923,0.0001980653,0.00007029895,0.000980741,0.000216284,0.00005577389,0.0006463816],"genre_scores_gemma":[0.9941459,0.0008498364,0.001197188,0.0003324721,0.00009200932,0.001323097,0.0005477201,0.00001730504,0.001494481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001724213,"threshold_uncertainty_score":0.005282819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02985596977875885,"score_gpt":0.318312273686907,"score_spread":0.2884563039081481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}