{"id":"W3036843612","doi":"10.1097/cji.0000000000000325","title":"A Phase I, Dose Escalation, Single Dose Trial of Oral Attenuated Salmonella typhimurium Containing Human IL-2 in Patients With Metastatic Gastrointestinal Cancers","year":2020,"lang":"en","type":"article","venue":"Journal of Immunotherapy","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Toxicity; Medicine; Flow cytometry; Adverse effect; Progressive disease; Regimen; Pharmacology; Immunology; Salmonella; Cancer; Internal medicine; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000172282,0.0001261814,0.0002743372,0.00007940237,0.00003187466,0.00002057714,0.0001311739,0.00002389601,0.00002668901],"category_scores_gemma":[0.00005349607,0.00009743214,0.00008950634,0.0001631663,0.00006493746,0.0000137642,0.00001555012,0.000122937,5.139188e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008444839,"about_ca_system_score_gemma":0.0002491855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001609747,"about_ca_topic_score_gemma":0.00007116497,"domain_scores_codex":[0.9988909,0.00009523025,0.0004293509,0.0001285052,0.0002716032,0.0001843848],"domain_scores_gemma":[0.9991084,0.00001289964,0.000402179,0.0001064243,0.0002765162,0.00009352064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3233337,0.002496848,0.03148512,0.00001897906,0.0005742384,0.00006109143,0.0003481172,0.0003542803,0.6316121,0.000001770065,0.0001880857,0.009525793],"study_design_scores_gemma":[0.7179219,0.1738241,0.03470191,0.0003344615,0.000102908,0.00005001083,0.0002501728,0.0001101167,0.07133413,0.00003378968,0.0009711419,0.0003653369],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989917,0.0002567509,0.0002758064,0.0001145928,0.00002908853,0.0002840146,0.00002532709,0.000001950636,0.00002075257],"genre_scores_gemma":[0.9989665,0.00003612942,0.0007776239,0.00008450264,0.00005831506,0.000005177762,0.00004304924,0.00001955735,0.000009143536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5602779,"threshold_uncertainty_score":0.3973168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02985596977875885,"score_gpt":0.318312273686907,"score_spread":0.2884563039081481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}