{"id":"W3036876824","doi":"10.1371/journal.pone.0232870","title":"Prognostic factors for changes in the timed 4-stair climb in patients with Duchenne muscular dystrophy, and implications for measuring drug efficacy: A multi-institutional collaboration","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Eli Lilly (Canada)","funders":"Italfarmaco; Astellas Pharma; FibroGen; Pfizer; Parent Project Muscular Dystrophy; Eli Lilly and Company","keywords":"Duchenne muscular dystrophy; Medicine; Placebo; Clinical trial; Physical medicine and rehabilitation; Internal medicine; Physical therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02124917,0.0004162559,0.000861224,0.001546719,0.0005141187,0.001733723,0.0007480126,0.0004916445,0.000575081],"category_scores_gemma":[0.03842281,0.0003128687,0.001216048,0.002744566,0.0004310731,0.0007761568,0.001327467,0.0005823347,0.0001183701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006868531,"about_ca_system_score_gemma":0.0008283266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004140505,"about_ca_topic_score_gemma":0.005004134,"domain_scores_codex":[0.9869363,0.009498932,0.001099254,0.001135333,0.00105695,0.000273201],"domain_scores_gemma":[0.9605867,0.01854425,0.01337369,0.003879936,0.002500165,0.0011152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003932164,0.00002319273,0.9965587,0.00001367731,0.0002532647,0.00001966242,0.00005207179,0.0003036557,0.00003150493,0.00001871835,0.00009481265,0.002237563],"study_design_scores_gemma":[0.00007721702,0.0002388649,0.9933243,0.00004291017,0.0003122482,0.0001433077,0.0002217189,0.005025312,0.0001205807,0.0001439753,0.0003287507,0.00002095267],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974076,0.0005606713,0.0008894532,0.0001223367,0.000009603519,0.00003212574,0.0006543129,0.000009227374,0.0003146152],"genre_scores_gemma":[0.9987576,0.00007361187,0.0005222697,0.00001745117,0.00001018102,0.00002587442,0.0005405351,0.000003935568,0.00004839967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02124917,"threshold_uncertainty_score":0.1123776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03585240569892816,"score_gpt":0.2332989973857995,"score_spread":0.1974465916868713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}