{"id":"W3036897859","doi":"10.1186/s13223-020-00442-0","title":"Efficacy of omalizumab in children, adolescents, and adults with severe allergic asthma: a systematic review, meta-analysis, and call for new trials using current guidelines for assessment of severe asthma","year":2020,"lang":"en","type":"review","venue":"Allergy Asthma and Clinical Immunology","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Omalizumab; Medicine; Asthma; Exacerbation; Guideline; Systematic review; Minimal clinically important difference; Meta-analysis; Pediatrics; Clinical trial; MEDLINE; Intensive care medicine; Physical therapy; Randomized controlled trial; Internal medicine; Immunoglobulin E; Immunology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0260608,0.002351317,0.01823357,0.006988865,0.0006102758,0.003513516,0.001890489,0.002308713,0.002307797],"category_scores_gemma":[0.04341763,0.001525369,0.03429245,0.005678334,0.001011307,0.002192473,0.001479801,0.001648139,0.000197797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003384182,"about_ca_system_score_gemma":0.005265144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006386907,"about_ca_topic_score_gemma":0.01619205,"domain_scores_codex":[0.9831907,0.008474929,0.004930007,0.00123407,0.001807175,0.0003631586],"domain_scores_gemma":[0.9713078,0.01997272,0.005565885,0.0009279563,0.001899979,0.000325756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001942802,0.0000339567,0.004288258,0.4941964,0.480229,0.0001042163,0.0001100614,0.0003385051,0.0002624121,0.0001640725,0.000670051,0.01766033],"study_design_scores_gemma":[0.0009255643,0.0002602569,0.004287027,0.05812922,0.9336292,0.00009804486,0.0000762266,0.0001759514,0.0001296532,0.0002360851,0.002028648,0.00002408212],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003041462,0.9957001,0.0002417004,0.0002944964,0.0001071843,0.0002685054,0.00018006,0.00001244618,0.0001540815],"genre_scores_gemma":[0.1635872,0.8292011,0.002937507,0.00173397,0.0003169662,0.001430515,0.0005289794,0.00002483999,0.000238933],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0260608,"threshold_uncertainty_score":0.1378244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1749673385983951,"score_gpt":0.4631636150304038,"score_spread":0.2881962764320087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}