{"id":"W3036916204","doi":"10.1016/j.stemcr.2020.05.014","title":"The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation","year":2020,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation; United States-Israel Binational Science Foundation; Rosetrees Trust","keywords":"Biology; Chromatin; Cell biology; Embryonic stem cell; Histone; Induced pluripotent stem cell; Chromatin remodeling; Cellular differentiation; Epigenetics; Bivalent chromatin; Acetylation; Transcriptional regulation; Regulation of gene expression; Genetics; Gene expression; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001163896,0.0003419811,0.000166604,0.0001825721,0.000129295,0.0003388908,0.0001355253,0.0001436982,0.001238837],"category_scores_gemma":[0.0001370374,0.0001760742,0.0001538802,0.0001129859,0.0001862366,0.0001604506,0.0002775011,0.0002457992,0.0005456309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049688,"about_ca_system_score_gemma":0.0002016853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005196686,"about_ca_topic_score_gemma":0.0009207355,"domain_scores_codex":[0.9998884,0.00001398633,0.00001150877,0.00003272464,0.00003436329,0.00001901796],"domain_scores_gemma":[0.9998804,0.00002341862,0.00003758279,0.0000151266,0.000009037849,0.00003438092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004086537,0.000002311245,0.0003202691,0.00001004064,0.000002164953,0.00002871486,0.000002895978,0.00002696645,0.9990048,0.00003896921,0.00001248971,0.000509625],"study_design_scores_gemma":[0.000007286397,0.00006988317,0.006256886,0.000002490014,0.000007894613,0.000260171,0.000008337635,0.0004292023,0.9910896,0.00002872938,0.001837179,0.000002285083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919443,0.001970558,0.003634502,0.00006317507,0.00001659208,0.00001531799,0.0005901728,0.0001662798,0.001599186],"genre_scores_gemma":[0.9961286,0.0004903045,0.001266432,0.00002608528,0.000006324701,0.000008504941,0.000706377,0.00003775832,0.001329716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001238837,"threshold_uncertainty_score":0.004144251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229311290219874,"score_gpt":0.2379571749099139,"score_spread":0.2256640620077152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}