{"id":"W3036965359","doi":"10.1158/2326-6074.tumimm18-b49","title":"Abstract B49: Development and characterization of a novel CA9 targeting dual-antibody T-cell engager for renal cell carcinoma","year":2020,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Cancer research; Antigen; Flow cytometry; T cell; Immunotherapy; Biology; Antibody; Clear cell renal cell carcinoma; Immunology; Medicine; Immune system; Renal cell carcinoma; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000200827,0.0003103864,0.0002851113,0.0001773551,0.0001321865,0.000391298,0.0004433966,0.000581931,0.0014015],"category_scores_gemma":[0.0002050884,0.0001111402,0.0002728777,0.0001293927,0.0001108368,0.0001457206,0.0001789996,0.0006294954,0.001266486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003305826,"about_ca_system_score_gemma":0.0002636005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007629832,"about_ca_topic_score_gemma":0.0008743026,"domain_scores_codex":[0.9998226,0.00002047643,0.00001181662,0.00003574812,0.00007783966,0.00003158819],"domain_scores_gemma":[0.9999225,0.000007533035,0.00001367959,0.000009148363,0.00002059491,0.00002646916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003579141,0.00005997106,0.00007178391,0.00001960564,0.000004249761,0.00004000962,0.000006661609,0.0002425613,0.9975453,0.00006703597,0.00008182483,0.001825094],"study_design_scores_gemma":[0.00003689067,0.000805355,0.0009247496,0.000007827438,0.00002260853,0.0003531672,0.00001193996,0.003150548,0.9854867,0.00003268136,0.009158629,0.000008857485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9555365,0.002403264,0.03372221,0.00034824,0.00009223667,0.0008272119,0.001495693,0.0003145519,0.005260086],"genre_scores_gemma":[0.9636462,0.001069375,0.02381555,0.0001917479,0.00002206661,0.0002177705,0.002594745,0.00005751878,0.008385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0014015,"threshold_uncertainty_score":0.004688501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1071352995095854,"score_gpt":0.3795956811928061,"score_spread":0.2724603816832206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}