{"id":"W3036971773","doi":"10.1053/j.gastro.2020.06.031","title":"IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":179,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Infection and Immunity; National Institute of Diabetes and Digestive and Kidney Diseases; Center for Cell Signaling in Gastroenterology, Mayo Clinic; National Cancer Institute; American Liver Foundation; National Institutes of Health; National Center for Advancing Translational Sciences; Mayo Foundation for Medical Education and Research; Mayo Clinic","keywords":"Steatohepatitis; Extracellular vesicles; Inflammation; Hepatocyte; Cell biology; Extracellular; Chemistry; Medicine; Immunology; Biology; Pathology; Fatty liver; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005000238,0.001106513,0.0007386971,0.0009469228,0.0003730354,0.000667338,0.0003782338,0.001193963,0.001979055],"category_scores_gemma":[0.0003721694,0.0005879623,0.0007176669,0.0003074123,0.0009306064,0.0007293393,0.00050002,0.002555202,0.0006379285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007223929,"about_ca_system_score_gemma":0.0003372533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003673953,"about_ca_topic_score_gemma":0.0008006755,"domain_scores_codex":[0.9994364,0.0001324679,0.00005200026,0.0001154939,0.00008947856,0.0001741081],"domain_scores_gemma":[0.9992841,0.00006839408,0.0002340826,0.00007193605,0.00004223208,0.0002992115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001684243,0.000220834,0.0002524405,0.00006128949,0.00001422082,0.0001428007,0.00003212471,0.0001530907,0.9963212,0.0002329131,0.00009504314,0.0007897319],"study_design_scores_gemma":[0.0004650984,0.001652919,0.008456282,0.00002881052,0.00008549636,0.0004434524,0.0002449499,0.002083216,0.9841793,0.0004238646,0.00190692,0.00002970763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941499,0.001211438,0.001860914,0.000647282,0.0001600359,0.00004779431,0.0005740187,0.0002386971,0.00110999],"genre_scores_gemma":[0.9916857,0.000870139,0.002360873,0.0002793162,0.00007542043,0.0001489838,0.000590104,0.0001589037,0.003830494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001979055,"threshold_uncertainty_score":0.006620586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009869429415439267,"score_gpt":0.2077339746151868,"score_spread":0.1978645451997475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}