{"id":"W3036971773","doi":"10.1053/j.gastro.2020.06.031","title":"IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":179,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Infection and Immunity; National Institute of Diabetes and Digestive and Kidney Diseases; Center for Cell Signaling in Gastroenterology, Mayo Clinic; National Cancer Institute; American Liver Foundation; National Institutes of Health; National Center for Advancing Translational Sciences; Mayo Foundation for Medical Education and Research; Mayo Clinic","keywords":"Steatohepatitis; Extracellular vesicles; Inflammation; Hepatocyte; Cell biology; Extracellular; Chemistry; Medicine; Immunology; Biology; Pathology; Fatty liver; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004947139,0.000184904,0.0001972194,0.00003426875,0.00003460298,0.00002004748,0.0001496755,0.00008986249,0.0000243078],"category_scores_gemma":[0.00002982143,0.0001663853,0.00005285732,0.00004869587,0.00008692323,0.00000944837,0.00008254476,0.00009778372,0.00001034854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001090495,"about_ca_system_score_gemma":0.0000272213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003440625,"about_ca_topic_score_gemma":0.0003038538,"domain_scores_codex":[0.9988667,0.0001010212,0.000209378,0.0003991005,0.0001031689,0.0003206469],"domain_scores_gemma":[0.9995388,0.000006887956,0.0001019875,0.0001705169,0.00003340015,0.000148376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009941973,0.000039954,0.4654499,0.00003424903,0.00003549054,0.00008201227,0.0001367791,0.0008237102,0.5318958,0.000007583815,0.00005499156,0.0004453454],"study_design_scores_gemma":[0.005980781,0.003353018,0.254539,0.00006675552,0.0000701992,0.00007791024,0.0002577249,0.007785462,0.7263573,0.00003857528,0.001108575,0.0003646273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967512,0.0002679607,0.001798027,0.0007714475,0.00003287975,0.00029047,0.00002194784,0.00002226066,0.00004374192],"genre_scores_gemma":[0.9984825,0.00009095982,0.0006886423,0.0003958134,0.00009088046,0.00004599381,0.0001637344,0.00002424162,0.00001727504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2109109,"threshold_uncertainty_score":0.6784995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009869429415439267,"score_gpt":0.2077339746151868,"score_spread":0.1978645451997475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}