{"id":"W3037054415","doi":"10.1016/j.copbio.2020.05.003","title":"Toward a systematic design of smart probiotics","year":2020,"lang":"en","type":"review","venue":"Current Opinion in Biotechnology","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Risk analysis (engineering); Synthetic biology; Biochemical engineering; Computer science; Biotechnology; Business; Engineering; Biology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002540466,0.0003448026,0.001365742,0.0002927469,0.00001333312,0.000007073258,0.000412861,0.0008901011,0.000001984338],"category_scores_gemma":[0.0003305766,0.0002901247,0.0002169369,0.0004777254,0.00009637095,0.00000151804,0.0001819391,0.0004109965,0.00001671547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003336963,"about_ca_system_score_gemma":0.0001536915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001080247,"about_ca_topic_score_gemma":1.606365e-7,"domain_scores_codex":[0.9981946,0.0001687768,0.0007994656,0.0005286371,0.00007986131,0.0002286532],"domain_scores_gemma":[0.9990213,0.00000911165,0.000397025,0.0004956786,0.00003960744,0.00003729995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002173455,0.0001582988,5.716686e-7,0.6815851,0.0001785912,8.833232e-7,0.00002631198,0.00002805654,0.005932666,0.0005599177,0.001305477,0.3102024],"study_design_scores_gemma":[0.0001309496,0.0002675656,7.619777e-8,0.03924722,0.000113534,0.00007134846,0.000007095029,0.00002048522,0.00260694,0.000008680588,0.9572423,0.0002838277],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000002193682,0.9844738,0.01082659,0.00005597713,0.003185474,0.001380198,0.00003139146,0.00004274674,0.000001644265],"genre_scores_gemma":[0.0000579552,0.9983172,0.0009968173,0.000001527004,0.0003289303,0.0001062422,0.0001444926,0.00003775308,0.000009037774],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9559368,"threshold_uncertainty_score":0.9999551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08447954483666019,"score_gpt":0.3275078441440784,"score_spread":0.2430282993074181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}