{"id":"W3037060562","doi":"10.3390/microorganisms8060950","title":"Experimental Strategies to Explore Drug Action and Resistance in Kinetoplastid Parasites","year":2020,"lang":"en","type":"review","venue":"Microorganisms","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Universiteit Antwerpen; Fonds Wetenschappelijk Onderzoek","keywords":"Mode of action; Biology; Drug resistance; Drug; Identification (biology); Neglected tropical diseases; African trypanosomiasis; Leishmaniasis; Drug discovery; Pharmacology; Computational biology; Trypanosomiasis; Medicine; Disease; Bioinformatics; Toxicology; Immunology; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005960259,0.0006929655,0.00118603,0.002158246,0.000278089,0.0009378314,0.0007575597,0.0009086105,0.004440004],"category_scores_gemma":[0.0005558446,0.0002979374,0.000653647,0.00147095,0.0005149934,0.001227344,0.0006342059,0.001394311,0.001894228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005485399,"about_ca_system_score_gemma":0.0008084179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006602017,"about_ca_topic_score_gemma":0.001372474,"domain_scores_codex":[0.999773,0.00004750689,0.0000236984,0.00004916839,0.00008306813,0.00002355998],"domain_scores_gemma":[0.9997883,0.00009251715,0.00003196417,0.00001458341,0.00005622977,0.00001641359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002013692,0.0002224611,0.000360503,0.0499126,0.0002125347,0.0004281224,0.0001389275,0.0006995295,0.05604493,0.01511198,0.01228027,0.8643867],"study_design_scores_gemma":[0.00004743839,0.0006177493,0.001734474,0.00317797,0.0003181237,0.001487677,0.0001085851,0.0002420344,0.01853038,0.003526316,0.970157,0.00005222804],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00124209,0.9921673,0.001178647,0.0003293143,0.0002148817,0.000044666,0.0001275984,0.00002968779,0.004665779],"genre_scores_gemma":[0.00656245,0.989461,0.001563866,0.0003286563,0.0001046906,0.0000547773,0.0001782741,0.000005871366,0.001740449],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004440004,"threshold_uncertainty_score":0.0148533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1050247336787051,"score_gpt":0.4069272046393855,"score_spread":0.3019024709606804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}