{"id":"W3037072523","doi":"10.2196/19538","title":"Statistical Issues and Lessons Learned From COVID-19 Clinical Trials With Lopinavir-Ritonavir and Remdesivir","year":2020,"lang":"en","type":"article","venue":"JMIR Public Health and Surveillance","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Lopinavir/ritonavir; Lopinavir; Coronavirus disease 2019 (COVID-19); Ritonavir; 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Medicine; Virology; Pandemic; Human immunodeficiency virus (HIV); Viral load; Antiretroviral therapy; Internal medicine; Outbreak; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.6730297,0.002428257,0.007437646,0.00502776,0.001618212,0.008003903,0.006173703,0.006828995,0.002842922],"category_scores_gemma":[0.7945861,0.001913907,0.006724588,0.005476872,0.01745551,0.008831288,0.004763432,0.0192666,0.0006420118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004711696,"about_ca_system_score_gemma":0.007203558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004119377,"about_ca_topic_score_gemma":0.003393012,"domain_scores_codex":[0.2359731,0.7087615,0.02352805,0.008434117,0.02225557,0.001047697],"domain_scores_gemma":[0.07415427,0.8733261,0.01347279,0.02224864,0.01528349,0.001514644],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.007456156,0.0004360739,0.04457758,0.007260611,0.01707931,0.001563483,0.005654769,0.04000421,0.001165389,0.1516805,0.07752884,0.645593],"study_design_scores_gemma":[0.004739081,0.007385224,0.02701413,0.01128487,0.005565886,0.001759304,0.001960872,0.1591569,0.002567904,0.6829646,0.09488357,0.0007175668],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.02817558,0.08810136,0.5476795,0.3131107,0.01282214,0.00199172,0.001144231,0.001004177,0.005970612],"genre_scores_gemma":[0.4872602,0.02531568,0.3460764,0.1017389,0.02979434,0.005595558,0.0008130526,0.001451967,0.001953909],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.3269703,"threshold_uncertainty_score":0.4032127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8432263555532094,"score_gpt":0.6657415311735724,"score_spread":0.177484824379637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}