{"id":"W3037094764","doi":"10.1186/s12935-020-01364-y","title":"β-catenin promotes MTX resistance of leukemia cells by down-regulating FPGS expression via NF-κB","year":2020,"lang":"en","type":"article","venue":"Cancer Cell International","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"Beijing Municipal Administration of Hospitals; Beijing Children's Hospital, Capital Medical University; Capital Medical University; National Natural Science Foundation of China","keywords":"Chromatin immunoprecipitation; Catenin; Cancer research; Immunoprecipitation; Gene knockdown; Flow cytometry; Deubiquitinating enzyme; NF-κB; Biology; Downregulation and upregulation; Apoptosis; Cell culture; Molecular biology; Cell biology; Signal transduction; Ubiquitin; Wnt signaling pathway; Gene expression; Promoter; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008108232,0.0001724999,0.0001508276,0.00001701378,0.00005034018,0.00002191795,0.0003868267,0.0001204443,0.0006223068],"category_scores_gemma":[0.00001616769,0.0001681599,0.00008110756,0.0000679189,0.00006797221,0.00001304893,0.0001350326,0.0000895923,0.000009599617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000095946,"about_ca_system_score_gemma":0.00014545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005863613,"about_ca_topic_score_gemma":0.00002306101,"domain_scores_codex":[0.9987935,0.00002544751,0.0003174668,0.0004027475,0.0002750842,0.0001857783],"domain_scores_gemma":[0.9993677,0.00001160997,0.0002267037,0.0001319712,0.0001771252,0.00008492511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001418759,0.0000179867,0.0006322456,0.00004652678,0.0000405734,7.410035e-7,0.0001834987,0.0003264807,0.9168166,0.000005481983,0.08124842,0.0005395488],"study_design_scores_gemma":[0.0005014818,0.00003618281,0.00005773246,0.00006266037,0.000009729554,3.713828e-7,0.00003713256,0.0003575883,0.9311798,0.00002931545,0.06753512,0.0001928444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974964,0.006473334,0.007948158,0.001254754,0.0009632009,0.0002991925,0.0001946388,0.0000414142,0.007861312],"genre_scores_gemma":[0.9904585,0.0004276698,0.002259114,0.0003996984,0.0004513593,0.00005458061,0.0002435817,0.00002978475,0.005675673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01549454,"threshold_uncertainty_score":0.685736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009262490263321873,"score_gpt":0.2311013287755856,"score_spread":0.2218388385122638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}