{"id":"W3037127874","doi":"10.1101/2020.06.27.175018","title":"Malaria in pregnancy regulates P-glycoprotein (P-gp/ <i>Abcb1a</i> ) and ABCA1 efflux transporters in the mouse visceral yolk sac","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ministério da Ciência, Tecnologia e Inovação; Bill and Melinda Gates Foundation","keywords":"Yolk sac; Biology; Conceptus; Endocrinology; Internal medicine; Chemistry; Fetus; Cell biology; Embryo; Pregnancy; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001334045,0.000203696,0.0001954541,0.0002103246,0.0001154451,0.0003356809,0.00009956535,0.0002215321,0.001261632],"category_scores_gemma":[0.0001251061,0.0002345932,0.0001690221,0.0001014156,0.0002562201,0.0001939811,0.0001497968,0.0006334233,0.0002980304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002657821,"about_ca_system_score_gemma":0.0001466634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007352852,"about_ca_topic_score_gemma":0.0007002458,"domain_scores_codex":[0.9998553,0.00002241808,0.000009414071,0.00003612619,0.00002559454,0.00005114065],"domain_scores_gemma":[0.9998674,0.00001408122,0.00006042275,0.000008481374,0.00001368521,0.00003584248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003338731,0.00002264967,0.0005278097,0.00003553987,0.000003300255,0.00005757539,0.00003290963,0.00002083899,0.9977421,0.0000980958,0.00006587518,0.001059444],"study_design_scores_gemma":[0.00005882456,0.0009071018,0.04287227,0.00002424931,0.00004855603,0.0005665298,0.0001844267,0.001176975,0.9504399,0.000172393,0.003537097,0.00001169493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994766,0.001584647,0.001523344,0.0002031479,0.00002274822,0.0000141042,0.0005222509,0.00008192661,0.001281817],"genre_scores_gemma":[0.9942471,0.0008647187,0.001199177,0.00008043046,0.000008045427,0.00003937507,0.0003236803,0.0000312136,0.003206163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001261632,"threshold_uncertainty_score":0.004220545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190555547914849,"score_gpt":0.2095991784055705,"score_spread":0.197693622926422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}