{"id":"W3037128218","doi":"10.1016/j.ijpddr.2020.06.004","title":"Mode of action of a formulation containing hydrazones and saponins against leishmania spp. Role in mitochondria, proteases and reinfection process","year":2020,"lang":"en","type":"article","venue":"International Journal for Parasitology Drugs and Drug Resistance","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; Alberta Innovates - Technology Futures; European Regional Development Fund; Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)","keywords":"Hederagenin; Cassia; Saponin; Leishmania; Biology; Amastigote; Mode of action; Pharmacology; Leishmania braziliensis; Chemistry; Biochemistry; Leishmaniasis; Stereochemistry; Parasite hosting; Cutaneous leishmaniasis; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001693928,0.0001040554,0.0003203206,0.0001698755,0.00008302781,0.00002309711,0.00005465243,0.00005444029,0.000001797406],"category_scores_gemma":[0.0004244779,0.00009300366,0.0000417652,0.00007969104,0.0001098225,0.0002551074,0.00002771182,0.0001672157,1.2864e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004338461,"about_ca_system_score_gemma":0.00006624747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004217131,"about_ca_topic_score_gemma":0.0002303631,"domain_scores_codex":[0.9989973,0.00004611068,0.000392961,0.0001909179,0.0002424423,0.0001303009],"domain_scores_gemma":[0.9989802,0.0001818956,0.0003054359,0.00004221689,0.0004091996,0.00008107396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01939298,0.0002726306,0.8408538,0.001265385,0.0005834896,0.000066328,0.01202585,0.0004014442,0.1077821,0.002712571,0.0003172448,0.01432621],"study_design_scores_gemma":[0.01925772,0.001801589,0.7788897,0.002700282,0.0002350087,0.0005356817,0.01555283,0.02992829,0.1340813,0.01434594,0.002099779,0.0005718903],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938774,0.001250546,0.000590567,0.003541394,0.00008580673,0.0004216682,0.00001337844,0.000007657272,0.0002115774],"genre_scores_gemma":[0.9981264,0.0009548956,0.000626179,0.00007014716,0.0001154599,0.00003541997,0.000007721489,0.000009447148,0.00005425514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06196413,"threshold_uncertainty_score":0.3792579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02143366472582082,"score_gpt":0.3657674706628508,"score_spread":0.34433380593703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}