{"id":"W3037128218","doi":"10.1016/j.ijpddr.2020.06.004","title":"Mode of action of a formulation containing hydrazones and saponins against leishmania spp. Role in mitochondria, proteases and reinfection process","year":2020,"lang":"en","type":"article","venue":"International Journal for Parasitology Drugs and Drug Resistance","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; Alberta Innovates - Technology Futures; European Regional Development Fund; Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)","keywords":"Hederagenin; Cassia; Saponin; Leishmania; Biology; Amastigote; Mode of action; Pharmacology; Leishmania braziliensis; Chemistry; Biochemistry; Leishmaniasis; Stereochemistry; Parasite hosting; Cutaneous leishmaniasis; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009915226,0.0002560423,0.0001747478,0.00008853808,0.00007066636,0.0001215845,0.0001526086,0.0002045884,0.0010565],"category_scores_gemma":[0.0000842223,0.00008031438,0.0001593241,0.00005512664,0.0001197085,0.0001464186,0.0000736548,0.0003451658,0.0001555816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009745439,"about_ca_system_score_gemma":0.0000974161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002801415,"about_ca_topic_score_gemma":0.0003221775,"domain_scores_codex":[0.9999433,0.00001405942,0.000004166724,0.00001196069,0.00001512793,0.00001144428],"domain_scores_gemma":[0.9999505,0.00001270282,0.00001542147,0.000003846784,0.000008249622,0.000009337799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003225956,0.00007643109,0.00008456205,0.00008554351,0.00000775177,0.00006016213,0.00001067297,0.00006585047,0.9966946,0.00004873379,0.0000466927,0.002496425],"study_design_scores_gemma":[0.00004416978,0.002312022,0.0009772158,0.000006272204,0.00002185026,0.0002029118,0.00001547524,0.0005011126,0.9944649,0.00001834757,0.00143261,0.000003107108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927111,0.003141525,0.002570263,0.0001412251,0.00006754931,0.0001003695,0.0001373632,0.00005494434,0.001075708],"genre_scores_gemma":[0.9939322,0.001361971,0.002707982,0.00004379079,0.00002272148,0.0000442021,0.0001029418,0.000006852586,0.001777258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0010565,"threshold_uncertainty_score":0.003534317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02143366472582082,"score_gpt":0.3657674706628508,"score_spread":0.34433380593703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}