{"id":"W3037140370","doi":"10.1186/s13063-020-04532-7","title":"Personalized dosing of nicotine replacement therapy versus standard dosing for the treatment of individuals with tobacco dependence: study protocol for a randomized placebo-controlled trial","year":2020,"lang":"en","type":"article","venue":"Trials","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Public Health Ontario; St. Michael's Hospital; Canada Research Chairs; McMaster University; University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Cancer Society Research Institute; Canada Research Chairs","keywords":"Medicine; Nicotine patch; Dosing; Nicotine replacement therapy; Smoking cessation; Placebo; Randomized controlled trial; Nicotine; Abstinence; Clinical trial; Internal medicine; Psychiatry; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0075787,0.0002519088,0.002699935,0.0000718976,0.0001321029,0.00003915984,0.00009748543,0.00007757497,0.0001472248],"category_scores_gemma":[0.002157061,0.0001190658,0.0006738559,0.0001450547,0.00008582517,0.00004755958,0.000008624541,0.00005441214,7.652255e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001125846,"about_ca_system_score_gemma":0.0003553611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002927095,"about_ca_topic_score_gemma":0.000004132246,"domain_scores_codex":[0.9964716,0.0008507204,0.001435405,0.0003169578,0.0007158167,0.0002095234],"domain_scores_gemma":[0.9908873,0.007117052,0.00136505,0.0002732891,0.0002936963,0.00006361384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9824787,0.00138574,0.0009624742,0.00004923761,0.002606481,4.632597e-7,0.005807147,0.00001505831,0.001039819,0.00003461862,0.0000511363,0.005569123],"study_design_scores_gemma":[0.9176414,0.05198678,0.00003599219,0.00009534584,0.004018811,4.706026e-7,0.001957463,0.00005834,0.02356138,0.00001076913,0.0005289296,0.0001043355],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.4355634,0.00005202973,0.001657938,0.0003586218,0.0001304528,0.5621625,0.00003751868,0.00002271324,0.00001476727],"genre_scores_gemma":[0.4036608,0.00001518614,0.0006752154,0.00002690847,0.0003404351,0.5952047,0.00001454614,0.00002689502,0.00003534484],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.06483731,"threshold_uncertainty_score":0.4855361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1920781026065839,"score_gpt":0.4533056675709335,"score_spread":0.2612275649643497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}