{"id":"W3037171273","doi":"10.3389/fnhum.2020.00242","title":"Secondary Worsening Following DYT1 Dystonia Deep Brain Stimulation: A Multi-country Cohort","year":2020,"lang":"en","type":"article","venue":"Frontiers in Human Neuroscience","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Nursing Research; Dystonia Coalition; Medtronic Japan; Wake Forest School of Medicine; Advanced Research Projects Agency; Parkinsonfonden; St. Jude Medical; Allergan; National Institutes of Health; Beijing Municipal Administration of Hospitals; National Natural Science Foundation of China; Boston Scientific Japan; Boston Scientific Corporation; University of Florida Foundation; Pfizer; Otsuka Pharmaceutical; Parkinson Alliance; Michael J. Fox Foundation for Parkinson's Research; National Organization for Rare Disorders; National Parkinson Foundation; U.S. Department of Defense","keywords":"Deep brain stimulation; Dystonia; Medicine; Cohort; Retrospective cohort study; Physical medicine and rehabilitation; Pediatrics; Clinical trial; Neurogenetics; Physical therapy; Disease; Internal medicine; Parkinson's disease; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001235611,0.0001959409,0.0003450786,0.0001094493,0.0002446309,0.00005201471,0.0002001185,0.00007165192,0.00003444288],"category_scores_gemma":[0.0003043445,0.000177322,0.00009965638,0.000572106,0.0001611098,0.000204961,0.00008505712,0.0003623368,0.000003029008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000485936,"about_ca_system_score_gemma":0.00004702126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009487276,"about_ca_topic_score_gemma":0.000006060154,"domain_scores_codex":[0.9982317,0.00006313116,0.0002905073,0.0006818483,0.0003519674,0.000380836],"domain_scores_gemma":[0.999443,0.00003257725,0.00007282592,0.0002148392,0.00001387824,0.0002228623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006905164,0.000196995,0.9874908,0.00002684737,0.00001137356,0.001247515,0.0003850191,0.001156198,0.006014293,0.0000320517,0.001799336,0.001570471],"study_design_scores_gemma":[0.004095098,0.0006780199,0.8912727,0.00004125718,0.00005925143,0.00001264731,0.0001230854,0.1011383,0.000179172,0.0003321005,0.001791875,0.0002765665],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972703,0.0003009044,0.02276972,0.001576187,0.0008459255,0.0006735692,0.000005036228,0.0001343078,0.0009913723],"genre_scores_gemma":[0.9818718,0.000007436062,0.003101835,0.01465713,0.00004307992,0.00002322492,0.00001134993,0.00002125673,0.0002628282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09998209,"threshold_uncertainty_score":0.723098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02588735326508081,"score_gpt":0.2868790081462312,"score_spread":0.2609916548811504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}