{"id":"W3037171273","doi":"10.3389/fnhum.2020.00242","title":"Secondary Worsening Following DYT1 Dystonia Deep Brain Stimulation: A Multi-country Cohort","year":2020,"lang":"en","type":"article","venue":"Frontiers in Human Neuroscience","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Nursing Research; Dystonia Coalition; Medtronic Japan; Wake Forest School of Medicine; Advanced Research Projects Agency; Parkinsonfonden; St. Jude Medical; Allergan; National Institutes of Health; Beijing Municipal Administration of Hospitals; National Natural Science Foundation of China; Boston Scientific Japan; Boston Scientific Corporation; University of Florida Foundation; Pfizer; Otsuka Pharmaceutical; Parkinson Alliance; Michael J. Fox Foundation for Parkinson's Research; National Organization for Rare Disorders; National Parkinson Foundation; U.S. Department of Defense","keywords":"Deep brain stimulation; Dystonia; Medicine; Cohort; Retrospective cohort study; Physical medicine and rehabilitation; Pediatrics; Clinical trial; Neurogenetics; Physical therapy; Disease; Internal medicine; Parkinson's disease; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006436868,0.0004193308,0.0005536763,0.0008272787,0.0008770503,0.0007911496,0.0003870997,0.000386819,0.002192824],"category_scores_gemma":[0.002025854,0.000303263,0.0005127496,0.0007039037,0.0004332326,0.000533125,0.0009824801,0.0004409105,0.0003968114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002892596,"about_ca_system_score_gemma":0.0002953432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00249883,"about_ca_topic_score_gemma":0.003046055,"domain_scores_codex":[0.9994239,0.0001280002,0.00006140816,0.0002207724,0.00006801751,0.00009797855],"domain_scores_gemma":[0.9986045,0.0001397628,0.0006937957,0.0001507718,0.0001453288,0.0002658818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001571073,0.00002313835,0.9977937,0.00000755019,0.00004426103,0.0005544891,0.0001186524,0.00004350527,0.0004225562,0.00001316019,0.00007350991,0.0007484197],"study_design_scores_gemma":[0.00001033921,0.0002797834,0.9934072,0.00000909569,0.00003866758,0.005201297,0.000575284,0.0001403924,0.0001268861,0.00002341432,0.0001777379,0.000009834936],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994862,0.00006236707,0.00008228255,0.00001495423,0.000001918934,0.000009510527,0.0002030714,0.000001655902,0.0001379139],"genre_scores_gemma":[0.9993972,0.00005430555,0.00006460966,0.00002400745,0.000004403994,0.000009620162,0.0003618636,0.000003467925,0.00008049142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00249883,"threshold_uncertainty_score":0.007335722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02588735326508081,"score_gpt":0.2868790081462312,"score_spread":0.2609916548811504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}