{"id":"W3037189089","doi":"10.1101/2020.06.26.174276","title":"Genome-Wide Association Study Meta-Analysis for Parkinson’s Disease Motor Subtypes","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; Medical Research Council; National Institutes of Health; Assistance publique-Hôpitaux de Paris; Fondation de France; Landspítali Háskólasjúkrahús; Demensförbundet; McGill University; Deutsche Forschungsgemeinschaft; University College London; Parkinson's UK; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; Multiple System Atrophy Coalition; Sol Goldman Charitable Trust; Agence Nationale de la Recherche; Center for Individualized Medicine, Mayo Clinic; Burroughs Wellcome Fund; Lewy Body Dementia Association; Huffington Foundation; American Parkinson Disease Association; Consortium canadien en neurodégénérescence associée au vieillissement; Parkinson Vereniging; Michael J. Fox Foundation for Parkinson's Research; Little Family Foundation; University of Glasgow; EU Joint Programme – Neurodegenerative Disease Research; Mayo Clinic; U.S. Department of Health and Human Services; Texas Children's Hospital; U.S. Department of Defense","keywords":"Genome-wide association study; Parkinson's disease; Allele; Essential tremor; Logistic regression; Internal medicine; Disease; Genetic association; Locus (genetics); Medicine; Oncology; Bioinformatics; Biology; Genetics; Genotype; Single-nucleotide polymorphism; Physical medicine and rehabilitation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01022449,0.003328251,0.009424206,0.004672335,0.001032671,0.003044937,0.002140217,0.002235756,0.003625972],"category_scores_gemma":[0.01675292,0.001364741,0.03825986,0.006352099,0.0006060526,0.001190805,0.001520259,0.002621112,0.0003566725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000861297,"about_ca_system_score_gemma":0.001399292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009116371,"about_ca_topic_score_gemma":0.009222105,"domain_scores_codex":[0.9898553,0.004629122,0.001404624,0.002926941,0.0007563351,0.0004275581],"domain_scores_gemma":[0.9882796,0.007709606,0.001366026,0.001547873,0.0007835755,0.0003133299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004223995,0.00002759165,0.09506354,0.00588246,0.8858479,0.0003369436,0.00003943542,0.001785959,0.0009130951,0.0002146613,0.001243152,0.004421286],"study_design_scores_gemma":[0.001090584,0.0002449232,0.04961221,0.0007809731,0.9422007,0.0003187627,0.00004970752,0.003041751,0.000383421,0.00082335,0.001420168,0.00003356752],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2744703,0.6889542,0.01838399,0.002135889,0.002082823,0.0003744155,0.01040148,0.0007909751,0.002405996],"genre_scores_gemma":[0.9522603,0.03770325,0.00429699,0.0008882133,0.000631377,0.0003954323,0.002914708,0.0001422787,0.0007674394],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01022449,"threshold_uncertainty_score":0.05407292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04378546463564043,"score_gpt":0.265168987372878,"score_spread":0.2213835227372376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}