{"id":"W3037220537","doi":"10.1101/2020.06.27.175158","title":"Repeated stimulation or tonic-signaling chimeric antigen receptors drive regulatory T cell exhaustion","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; BC Children's Hospital","keywords":"Chimeric antigen receptor; Stimulation; Immunology; Autoimmunity; Cell therapy; Regulatory T cell; Biology; Receptor; T-cell receptor; Immune system; T cell; Immunotherapy; Cell biology; Neuroscience; Stem cell; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002197968,0.0001882087,0.0001967225,0.000109186,0.0000814807,0.0002633124,0.0001237926,0.000230565,0.001832417],"category_scores_gemma":[0.0001061599,0.00008016457,0.0001637696,0.00009668905,0.0002091573,0.0001273626,0.0001735933,0.0004891936,0.0003807627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001289728,"about_ca_system_score_gemma":0.0001535513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001980029,"about_ca_topic_score_gemma":0.0002079243,"domain_scores_codex":[0.9998487,0.00003130379,0.000009943346,0.00003030504,0.00003255364,0.00004717692],"domain_scores_gemma":[0.9999202,0.00002134336,0.00001828762,0.00001599097,0.000006012207,0.00001824686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001343907,0.00002923264,0.0002595789,0.00001583404,0.000003571645,0.00003579664,0.000009855244,0.00009872736,0.9979575,0.0001813749,0.00006133923,0.001212819],"study_design_scores_gemma":[0.00003338006,0.0004912626,0.001757136,0.000004605054,0.00001409661,0.0002583965,0.0000253731,0.001455365,0.9936106,0.0001488742,0.002198084,0.000002832671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945738,0.0005690617,0.003072016,0.00008849725,0.00002991371,0.00001382346,0.0001289856,0.00006929919,0.001454751],"genre_scores_gemma":[0.9967181,0.0001812925,0.001345566,0.00005512352,0.00001286481,0.00001208155,0.0001525348,0.00001503164,0.001507497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001832417,"threshold_uncertainty_score":0.006130099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03059861328805237,"score_gpt":0.2725001237228235,"score_spread":0.2419015104347711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}