{"id":"W3037267465","doi":"10.1089/hum.2020.111","title":"CRISPR/Cas9 Editing: Sparking Discussion on Safety in Light of the Need for New Therapeutics","year":2020,"lang":"en","type":"review","venue":"Human Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Genome editing; CRISPR; Cas9; Computational biology; Function (biology); Biology; Genome; Transcription activator-like effector nuclease; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638403,0.0003818809,0.0007068972,0.00006466243,0.0001016203,0.00002347867,0.0004748712,0.0002884195,0.00001175115],"category_scores_gemma":[0.00001535405,0.000216289,0.0004545084,0.0001500316,0.00003319818,0.000001330804,0.00009092903,0.0002208119,0.000001445746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002955456,"about_ca_system_score_gemma":0.0001541047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004543273,"about_ca_topic_score_gemma":0.00001589333,"domain_scores_codex":[0.9985674,0.00008782176,0.0005178119,0.000417696,0.0001483432,0.0002608961],"domain_scores_gemma":[0.9990864,0.00002205167,0.000243945,0.0005607439,0.00002612603,0.0000607708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008019866,0.00006179805,0.000006532464,0.000861195,0.0002112566,0.000001381132,0.000270111,0.00008525027,0.04849487,0.00008971996,0.00123062,0.9486071],"study_design_scores_gemma":[0.0005820885,0.000313494,0.00001343202,0.001001985,0.00007568466,0.000004384957,0.00001829775,0.000007337223,0.03564793,0.00004974197,0.9620278,0.0002577445],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001745737,0.9959114,0.001736215,0.0003300429,0.0004299143,0.001075868,0.0000323613,0.00001229114,0.0002972924],"genre_scores_gemma":[0.001082256,0.9959397,0.0002667051,0.0001930618,0.001615052,0.00005211307,0.0001355264,0.0001076264,0.000607952],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9607973,"threshold_uncertainty_score":0.8820008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05265272412316521,"score_gpt":0.3753935562712434,"score_spread":0.3227408321480782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}