{"id":"W3037267465","doi":"10.1089/hum.2020.111","title":"CRISPR/Cas9 Editing: Sparking Discussion on Safety in Light of the Need for New Therapeutics","year":2020,"lang":"en","type":"review","venue":"Human Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Genome editing; CRISPR; Cas9; Computational biology; Function (biology); Biology; Genome; Transcription activator-like effector nuclease; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001418472,0.0006595493,0.001181054,0.001463675,0.000302756,0.001185227,0.0009341897,0.001669733,0.002847432],"category_scores_gemma":[0.001632393,0.0002300715,0.0005493323,0.001358627,0.0008421479,0.001876531,0.0007133764,0.003101217,0.001121847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008333299,"about_ca_system_score_gemma":0.001400873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007918816,"about_ca_topic_score_gemma":0.001099404,"domain_scores_codex":[0.9995771,0.0000885392,0.00005387954,0.00007480861,0.0001614951,0.00004425232],"domain_scores_gemma":[0.998938,0.0007148724,0.00007081962,0.00002539332,0.0001780774,0.000072836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008323362,0.00004359331,0.000109833,0.01364807,0.00006917216,0.0003098621,0.00009004379,0.0004296716,0.002676937,0.01315739,0.05467097,0.9147113],"study_design_scores_gemma":[0.00001254584,0.00005495378,0.0002846282,0.002111647,0.00005660521,0.000921117,0.00004360276,0.00008415464,0.0006750958,0.004001113,0.9917355,0.00001894664],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001135833,0.9966351,0.0003102776,0.00132471,0.0004263551,0.0000030897,0.00001763035,0.00001305813,0.00115621],"genre_scores_gemma":[0.001003564,0.9967763,0.0002965483,0.0009958359,0.0003487435,0.000006404924,0.00003190893,0.000003665261,0.0005370398],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002847432,"threshold_uncertainty_score":0.009525597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05265272412316521,"score_gpt":0.3753935562712434,"score_spread":0.3227408321480782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}