{"id":"W3037287986","doi":"10.1242/dev.190330","title":"How affinity of the ELT-2 GATA factor binding to <i>cis-</i>acting regulatory sites controls <i>Caenorhabditis elegans</i> intestinal gene transcription","year":2020,"lang":"en","type":"article","venue":"Development","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Children's Hospital Foundation","keywords":"Biology; Transcription factor; Gene; Caenorhabditis elegans; Genetics; GATA transcription factor; Molecular biology; Cell biology; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000162637,0.0002269836,0.0002284671,0.0000321524,0.0001673378,0.00006058597,0.0003886182,0.0001082568,0.00001476098],"category_scores_gemma":[0.0001930196,0.000198052,0.00009906285,0.0001353988,0.00005841191,0.000008872556,0.0001633557,0.0001406747,0.000007454198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003671795,"about_ca_system_score_gemma":0.0001692812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005928055,"about_ca_topic_score_gemma":0.00004601827,"domain_scores_codex":[0.998615,0.00006977288,0.0003164575,0.0004100783,0.0002854926,0.0003031708],"domain_scores_gemma":[0.9992323,0.00001712453,0.0001579344,0.0003004397,0.0001268348,0.0001653993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004130944,0.00003068709,0.004802882,0.00004118154,0.0000543989,0.000001535335,0.001923893,0.00007597712,0.9899442,0.00000780845,0.000562195,0.002513891],"study_design_scores_gemma":[0.0003883499,0.0001330389,0.01540784,0.00002676145,0.00002195359,0.000007205231,0.0001858506,0.00002432143,0.9633048,0.000007221539,0.02025104,0.0002416897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705211,0.0001931016,0.02695094,0.001662537,0.0001982352,0.0003441842,0.00005018638,0.00002343824,0.00005628879],"genre_scores_gemma":[0.9882786,0.00002032957,0.01002058,0.001205201,0.0001890197,0.0000178414,0.00007973392,0.00003181137,0.0001569055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02663951,"threshold_uncertainty_score":0.8076326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02457228836477726,"score_gpt":0.2125319376324325,"score_spread":0.1879596492676553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}