{"id":"W3037306288","doi":"10.1007/s40265-020-01348-2","title":"Ripretinib: First Approval","year":2020,"lang":"en","type":"review","venue":"Drugs","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PDGFRA; Medicine; GiST; Imatinib; PDGFRB; Tyrosine kinase; Receptor tyrosine kinase; Tyrosine-kinase inhibitor; Platelet-derived growth factor receptor; Imatinib mesylate; Sunitinib; Targeted therapy; Cancer research; Growth factor receptor; Pharmacology; Oncology; Internal medicine; Cancer; Stromal cell; Receptor; Growth factor; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001005975,0.0003400567,0.001410818,0.00009583015,0.00005365141,0.00002568141,0.0001534058,0.00007442744,0.0002825432],"category_scores_gemma":[0.0002399162,0.0002300507,0.0005936836,0.0002504114,0.00006332347,0.00001680289,0.0001079473,0.0005611927,0.002962461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001718828,"about_ca_system_score_gemma":0.000446976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001870949,"about_ca_topic_score_gemma":9.572105e-7,"domain_scores_codex":[0.9984523,0.00005371999,0.0003202007,0.0004205452,0.0003843388,0.0003688898],"domain_scores_gemma":[0.9988858,0.0001362013,0.0001064638,0.0003572431,0.00004332917,0.0004710371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002367002,0.0001186295,0.00001245919,0.02059739,0.0001948991,0.001956643,0.00004346046,7.047474e-9,2.631388e-8,0.00008734749,0.005958409,0.971007],"study_design_scores_gemma":[0.0003988474,0.0004258007,0.000003795827,0.01236149,0.0007163394,0.001244922,0.00001537149,0.000003324111,5.654262e-7,0.000009786445,0.9846891,0.0001307226],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000001490188,0.9799324,0.000006415586,0.0005458912,0.00005572341,0.001112354,0.00004717472,0.0001067118,0.01819188],"genre_scores_gemma":[0.00001401313,0.9960738,0.001016397,0.00005272971,0.0003775368,0.0001823638,0.0002992664,0.00006723307,0.001916699],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9787306,"threshold_uncertainty_score":0.9978138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06558843503017232,"score_gpt":0.3746732657524908,"score_spread":0.3090848307223185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}