{"id":"W3037306288","doi":"10.1007/s40265-020-01348-2","title":"Ripretinib: First Approval","year":2020,"lang":"en","type":"review","venue":"Drugs","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PDGFRA; Medicine; GiST; Imatinib; PDGFRB; Tyrosine kinase; Receptor tyrosine kinase; Tyrosine-kinase inhibitor; Platelet-derived growth factor receptor; Imatinib mesylate; Sunitinib; Targeted therapy; Cancer research; Growth factor receptor; Pharmacology; Oncology; Internal medicine; Cancer; Stromal cell; Receptor; Growth factor; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004436389,0.0007362282,0.0008745739,0.001099864,0.0002428306,0.00117404,0.0007319364,0.001222098,0.02611103],"category_scores_gemma":[0.0008731338,0.0001809684,0.0008761203,0.0007949928,0.0002375252,0.0007922801,0.0004485498,0.001931044,0.01095987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006356409,"about_ca_system_score_gemma":0.001072703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007640425,"about_ca_topic_score_gemma":0.002358021,"domain_scores_codex":[0.9997782,0.00004014,0.00002557198,0.00003404819,0.00009313057,0.00002886151],"domain_scores_gemma":[0.9997987,0.00004598198,0.00004232497,0.000006030701,0.00006928441,0.00003771098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003615441,0.00007854511,0.0000934971,0.01029739,0.00009966276,0.0002822154,0.00003494315,0.0001662385,0.002224617,0.002895845,0.1929418,0.7905238],"study_design_scores_gemma":[0.0002379067,0.0001521634,0.000289432,0.002186701,0.00007415479,0.0007775658,0.00001026803,0.00004327395,0.0004690351,0.0005526278,0.9951971,0.000009636433],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001085725,0.9555513,0.0004268766,0.002489367,0.002309128,0.0001240748,0.001262128,0.0001799848,0.03657147],"genre_scores_gemma":[0.009543313,0.9566363,0.0008988042,0.005172892,0.00119085,0.0001494657,0.002167771,0.00003769464,0.02420286],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02611103,"threshold_uncertainty_score":0.08735013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06558843503017232,"score_gpt":0.3746732657524908,"score_spread":0.3090848307223185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}