{"id":"W3037354511","doi":"10.1242/jcs.245985","title":"Effects of a local auxiliary protein on the two-dimensional affinity of a TCR–peptide MHC interaction","year":2020,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"H2020 European Research Council; Australian Research Council; Medical Research Council; Wellcome Trust","keywords":"Biology; T-cell receptor; Jurkat cells; Major histocompatibility complex; Receptor; T cell; Cell biology; Ligand (biochemistry); Plasma protein binding; MHC restriction; Molecular biology; Antigen; Biophysics; Immune system; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001829494,0.0003132203,0.0003597396,0.0001157346,0.0001750677,0.0006057079,0.0003245296,0.0002517927,0.001797654],"category_scores_gemma":[0.0003880334,0.0001900738,0.0001529109,0.0001622858,0.0003389696,0.0001988692,0.0003853339,0.0006334076,0.0003584433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000390336,"about_ca_system_score_gemma":0.000149389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007962169,"about_ca_topic_score_gemma":0.000904642,"domain_scores_codex":[0.9997316,0.0000745966,0.00002298448,0.00004770714,0.00006450007,0.00005865493],"domain_scores_gemma":[0.9995492,0.0001972902,0.00006029285,0.00004507254,0.00003435,0.0001138523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008749657,0.00001446515,0.00008282785,0.0000124225,0.000002574546,0.00001219786,0.000006372377,0.00003398502,0.9996141,0.00001733461,0.000006710677,0.000109457],"study_design_scores_gemma":[0.00001527874,0.0001463335,0.003753161,0.000003702412,0.00001215832,0.00006859332,0.0000223858,0.001527867,0.9939418,0.00001289896,0.0004905634,0.000005188404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986645,0.0002636467,0.0006728822,0.00002442925,0.000006885304,0.000005429672,0.00005617107,0.00001271813,0.0002933858],"genre_scores_gemma":[0.9985797,0.0001351088,0.0006689639,0.00002572869,0.000004189504,0.00001139648,0.0001313726,0.00001451929,0.0004290424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001797654,"threshold_uncertainty_score":0.006013751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01181637954912325,"score_gpt":0.2319646786599169,"score_spread":0.2201482991107936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}