{"id":"W3037354931","doi":"10.1182/blood.2019003846","title":"Interleukin-18 and cytotoxic impairment are independent and synergistic causes of murine virus-induced hyperinflammation","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; Rheumatology Research Foundation","keywords":"Immunology; Cytotoxic T cell; Perforin; Hemophagocytic lymphohistiocytosis; Biology; CD8; Immunopathology; Medicine; Antigen; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001075945,0.0001254309,0.000315171,0.00007926201,0.00004351367,0.00001677862,0.0000543627,0.00006590655,0.0001287157],"category_scores_gemma":[0.0001515303,0.0001082465,0.00003608688,0.00009914609,0.00006653853,0.00007478968,0.0001235604,0.0001553922,0.00001005547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001389442,"about_ca_system_score_gemma":0.00006621563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003924242,"about_ca_topic_score_gemma":0.00001413565,"domain_scores_codex":[0.9990472,0.00003289944,0.0003080364,0.0002073899,0.0002449924,0.0001594411],"domain_scores_gemma":[0.9995,0.00002834677,0.0001093521,0.0001548222,0.00006569006,0.0001417266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002573079,0.0003432321,0.05442465,0.0009549517,0.0001847152,0.0001624672,0.001172567,0.00000185651,0.9405841,0.00006744207,0.00008443616,0.001762293],"study_design_scores_gemma":[0.006207376,0.001658458,0.4112439,0.0002574345,0.0001897928,0.00007977526,0.001373751,0.0003171226,0.5779482,0.00003015788,0.0005024704,0.0001915644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980833,0.0005935794,0.00001604136,0.0004997107,0.00001576041,0.000377037,0.000006382652,0.00003523975,0.000372961],"genre_scores_gemma":[0.9994344,0.0002522536,0.00004204938,0.0001120322,0.00005073501,0.00002309162,0.000007814758,0.00001710287,0.00006049803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3626359,"threshold_uncertainty_score":0.4414164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03178143133559298,"score_gpt":0.2754787291162499,"score_spread":0.2436972977806569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}