{"id":"W3037375356","doi":"10.1007/s13402-020-00535-3","title":"Enhanced immunogenicity of leukemia-derived exosomes via transfection with lentiviral vectors encoding costimulatory molecules","year":2020,"lang":"en","type":"article","venue":"Cellular Oncology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Natural Science Foundation of China","keywords":"CD80; CD86; CTL*; Leukemia; Immune system; Cytotoxic T cell; Biology; Immunology; Immunogenicity; Cancer research; Dendritic cell; T cell; Myeloid leukemia; CD40; In vitro; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002204831,0.0003884712,0.0002048267,0.0002143449,0.0001147506,0.000373127,0.0001600269,0.0003424947,0.0006827052],"category_scores_gemma":[0.0001254098,0.0001159699,0.0002786506,0.0001147297,0.0001852614,0.0002880451,0.0002535948,0.0005115236,0.0002290007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003066506,"about_ca_system_score_gemma":0.0002013642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001905663,"about_ca_topic_score_gemma":0.000131487,"domain_scores_codex":[0.9998235,0.00002754277,0.00002577813,0.0000304912,0.0000510245,0.00004171343],"domain_scores_gemma":[0.9999192,0.00001183006,0.00003158073,0.000009628179,0.00001158074,0.00001624239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001238475,0.00006800854,0.0001868717,0.00004447871,0.000008697608,0.00003003889,0.00001593588,0.0001012149,0.9971426,0.0002277676,0.0000509173,0.001999648],"study_design_scores_gemma":[0.00004776471,0.0004509743,0.001194302,0.000009039635,0.00002969168,0.000129758,0.00001389124,0.001847192,0.9941313,0.00005624527,0.00208523,0.000004567463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910493,0.0008472071,0.006784677,0.00009590849,0.00005238823,0.00005849649,0.0001708732,0.0001051413,0.0008360797],"genre_scores_gemma":[0.9939925,0.0005261535,0.003462238,0.00003729032,0.00001542562,0.00005866932,0.0003762696,0.00001938839,0.001512041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006827052,"threshold_uncertainty_score":0.002283871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01105488443752335,"score_gpt":0.2331499335040378,"score_spread":0.2220950490665144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}