{"id":"W3037375356","doi":"10.1007/s13402-020-00535-3","title":"Enhanced immunogenicity of leukemia-derived exosomes via transfection with lentiviral vectors encoding costimulatory molecules","year":2020,"lang":"en","type":"article","venue":"Cellular Oncology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Natural Science Foundation of China","keywords":"CD80; CD86; CTL*; Leukemia; Immune system; Cytotoxic T cell; Biology; Immunology; Immunogenicity; Cancer research; Dendritic cell; T cell; Myeloid leukemia; CD40; In vitro; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000137849,0.0002605166,0.0003629162,0.00004755131,0.00008591128,0.000009462172,0.0002826102,0.0002792112,0.00005442285],"category_scores_gemma":[0.00006784034,0.0002616892,0.0001965164,0.0001569563,0.0003176451,0.00001069919,0.00009271823,0.0001954011,0.00001379912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001005389,"about_ca_system_score_gemma":0.0003141241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001634517,"about_ca_topic_score_gemma":0.00001438181,"domain_scores_codex":[0.9983793,0.0002286992,0.0003644134,0.0005313958,0.0001732445,0.0003229057],"domain_scores_gemma":[0.9991686,0.00003131103,0.0001876412,0.0003369875,0.0001064797,0.0001689502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008882445,0.000122743,0.0004584928,0.00007284318,0.0001657266,0.00004006271,0.000281144,0.001239964,0.9944739,0.00003004217,0.00004250783,0.002184317],"study_design_scores_gemma":[0.001729152,0.001596921,0.0003967735,0.00001530937,0.0001138301,0.00001087111,0.000139806,0.000727442,0.9937369,0.0000224854,0.001227177,0.0002833331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8673119,0.001708735,0.1296274,0.00006250082,0.0001314635,0.0003135736,0.0000126809,0.00003466462,0.0007970692],"genre_scores_gemma":[0.9983135,0.0001143245,0.00095284,0.0002035888,0.000168461,0.00002798461,0.0001289979,0.00005034397,0.0000399876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1310016,"threshold_uncertainty_score":0.9999835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01105488443752335,"score_gpt":0.2331499335040378,"score_spread":0.2220950490665144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}