{"id":"W3037389408","doi":"10.1038/s41380-020-0828-z","title":"Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction","year":2020,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Università degli Studi di Salerno; Universität Zürich; Eidgenössische Technische Hochschule Zürich","keywords":"Nucleus accumbens; Glutamatergic; Glutamate receptor; Addiction; Neuroscience; Pharmacology; NMDA receptor; Craving; Psychology; Basal ganglia; Dopamine; Medicine; Internal medicine; Central nervous system; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176061,0.0002434344,0.0002180054,0.0001554502,0.0001094928,0.000104354,0.0007200734,0.00007844737,0.0001248718],"category_scores_gemma":[0.00007535436,0.0002155238,0.000125925,0.001159577,0.00009970355,0.0001849465,0.0000579074,0.0005154218,0.0001210269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004004884,"about_ca_system_score_gemma":0.0000446649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005380813,"about_ca_topic_score_gemma":0.00005487474,"domain_scores_codex":[0.9976294,0.0004236637,0.0004288346,0.0006275298,0.0004472601,0.0004433023],"domain_scores_gemma":[0.9993024,0.00003254133,0.00009769649,0.0004467587,0.00001196001,0.0001086049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000559024,0.0002828403,0.01688857,0.00002412437,0.000002533264,0.0003661206,0.001060244,0.0001402413,0.9782425,0.0008629744,0.0006394804,0.001434445],"study_design_scores_gemma":[0.007632768,0.001332271,0.2704836,0.0002465838,0.0001035664,0.0002618342,0.0009276017,0.0009238769,0.7052395,0.002036782,0.009133302,0.001678346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884366,0.00008270251,0.00007680478,0.009886556,0.0003047012,0.0006460036,0.0000401051,0.0001269057,0.0003995762],"genre_scores_gemma":[0.9824356,0.00001593259,0.0001554338,0.01719459,0.0000548775,0.00008659376,0.000005396946,0.00004773127,0.000003798215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.273003,"threshold_uncertainty_score":0.8788805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03019790840480197,"score_gpt":0.2900649812315831,"score_spread":0.2598670728267811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}