{"id":"W3037432455","doi":"10.1002/cbic.202000254","title":"Cationic RuII Cyclopentadienyl Complexes with Antifungal Activity against Several Candida Species","year":2020,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; National Institutes of Health; Armand-Frappier Foundation","keywords":"Ruthenium; Cyclopentadienyl complex; Cationic polymerization; Fluconazole; Mode of action; Antifungal; Chemistry; Mechanism of action; Intracellular; Reactive oxygen species; Biological activity; Stereochemistry; Biochemistry; In vitro; Biology; Microbiology; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001216932,0.0004171418,0.000218881,0.0001163011,0.0001193442,0.0003160537,0.0003605713,0.000328526,0.003029171],"category_scores_gemma":[0.0001858504,0.0001286976,0.0001222627,0.0001516524,0.0002031711,0.0001865124,0.0002266268,0.0003732478,0.0005095561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002458664,"about_ca_system_score_gemma":0.0001273147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005740552,"about_ca_topic_score_gemma":0.0003725677,"domain_scores_codex":[0.9998847,0.00001998991,0.00001092044,0.00002371313,0.00003082875,0.00002975444],"domain_scores_gemma":[0.9999322,0.00001183096,0.00002034878,0.000008260192,0.00001112457,0.00001623999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005929294,0.00006453156,0.0001710607,0.0002563846,0.00002277738,0.0001260945,0.00003986867,0.0009591396,0.9900614,0.000672402,0.0007448087,0.006288589],"study_design_scores_gemma":[0.0001066135,0.001057724,0.001273449,0.0000150967,0.00003924337,0.0002749689,0.00003844211,0.002828982,0.9869708,0.00009365737,0.007279481,0.00002159238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857848,0.002494975,0.002843072,0.0002381036,0.0001055922,0.00004918839,0.000220141,0.000197092,0.008066919],"genre_scores_gemma":[0.9957095,0.0004997188,0.001233411,0.0001020907,0.0000122038,0.00002310518,0.0002051153,0.00002678919,0.002188028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003029171,"threshold_uncertainty_score":0.01013356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03349667986404767,"score_gpt":0.2300208046906533,"score_spread":0.1965241248266057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}