{"id":"W3037432455","doi":"10.1002/cbic.202000254","title":"Cationic RuII Cyclopentadienyl Complexes with Antifungal Activity against Several Candida Species","year":2020,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; National Institutes of Health; Armand-Frappier Foundation","keywords":"Ruthenium; Cyclopentadienyl complex; Cationic polymerization; Fluconazole; Mode of action; Antifungal; Chemistry; Mechanism of action; Intracellular; Reactive oxygen species; Biological activity; Stereochemistry; Biochemistry; In vitro; Biology; Microbiology; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001126355,0.000277413,0.0003334035,0.00001560601,0.000268308,0.00009923554,0.0002990827,0.0001543634,0.001491725],"category_scores_gemma":[0.0001413931,0.0002122493,0.0001137629,0.0001823873,0.0001705249,0.0001373901,0.0001505385,0.0002268856,0.00007876107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001050508,"about_ca_system_score_gemma":0.00008030496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001809109,"about_ca_topic_score_gemma":0.000005055728,"domain_scores_codex":[0.9985397,0.00002689617,0.0002283952,0.0005367224,0.0003255718,0.0003427039],"domain_scores_gemma":[0.9992076,0.00008529027,0.0001474763,0.0002875853,0.00009046184,0.0001816214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002021441,0.0001864394,0.006145012,0.0000924217,0.00007701515,0.000006453618,0.000441048,0.0001003805,0.9864992,0.00007642601,0.003322374,0.002851006],"study_design_scores_gemma":[0.0006804882,0.00007471309,0.004611554,0.00004453919,0.00003850901,0.000006107494,0.0003139444,0.002092083,0.9800116,0.00002198486,0.01176108,0.0003433266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9516008,0.00008311688,0.00005112162,0.001518028,0.00001738376,0.0001178896,0.00006326201,0.0001526636,0.04639574],"genre_scores_gemma":[0.9968576,0.00004302025,0.0002219334,0.0007752972,0.0004108125,0.00002772184,0.0002104541,0.00002430018,0.001428849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04525682,"threshold_uncertainty_score":0.9994211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03349667986404767,"score_gpt":0.2300208046906533,"score_spread":0.1965241248266057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}