{"id":"W3037437643","doi":"10.1084/jem.20191537","title":"Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing","year":2020,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Christie (Canada); McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Feinstein Institutes for Medical Research; China Scholarship Council; Kenneth Rainin Foundation","keywords":"Germinal center; Antigen; Cell biology; B cell; B-cell receptor; breakpoint cluster region; Naive B cell; Ubiquitin ligase; CD40; Molecular biology; Antigen processing; Chemistry; Ubiquitin; Biology; Antigen presentation; T cell; Antigen-presenting cell; Antibody; Cytotoxic T cell; Immunology; Receptor; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002294437,0.0004562931,0.0002574587,0.0004286356,0.0003129644,0.0009165516,0.0006266399,0.0005321545,0.002046721],"category_scores_gemma":[0.0002319855,0.0001866469,0.0002532169,0.0001643101,0.0005129608,0.000548319,0.0005096809,0.0008333148,0.000768766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009788069,"about_ca_system_score_gemma":0.0005307773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001114136,"about_ca_topic_score_gemma":0.001468604,"domain_scores_codex":[0.9996746,0.00004340642,0.0000278597,0.00006280083,0.00008400939,0.0001073374],"domain_scores_gemma":[0.9997261,0.00002363942,0.00007707327,0.00002588729,0.00002212641,0.0001250697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003327191,0.00006556516,0.0003551462,0.0000751742,0.00000722297,0.00008469918,0.00001811793,0.0001068528,0.9945554,0.0008660467,0.0001397551,0.003393434],"study_design_scores_gemma":[0.00007899044,0.0001877019,0.002959098,0.000008517863,0.00001166599,0.0002826378,0.00002406749,0.001169603,0.9908153,0.0001686417,0.004284384,0.000009321539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752814,0.00844542,0.008460664,0.0004145506,0.0001077023,0.0001105669,0.0007468857,0.0004942242,0.005938742],"genre_scores_gemma":[0.9896543,0.0008283333,0.004708383,0.0001198302,0.00002673252,0.00007545295,0.0003878425,0.00004288667,0.004156223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002046721,"threshold_uncertainty_score":0.007101834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0139069842214958,"score_gpt":0.2549067283700313,"score_spread":0.2409997441485355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}