{"id":"W3037446541","doi":"10.1007/s00204-020-02784-5","title":"Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens","year":2020,"lang":"en","type":"article","venue":"Archives of Toxicology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"U.S. Environmental Protection Agency","keywords":"Chemical safety; Carcinogen; Toxicology; Environmental health; Chemistry; Risk analysis (engineering); Medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09743899,0.002864846,0.0025627,0.01175607,0.002098578,0.007210013,0.009946889,0.01091226,0.004488208],"category_scores_gemma":[0.04416905,0.0009799915,0.005174435,0.007583608,0.006018354,0.005723179,0.009150558,0.009998285,0.004173731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00723511,"about_ca_system_score_gemma":0.04615028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02140701,"about_ca_topic_score_gemma":0.01657932,"domain_scores_codex":[0.9304119,0.01926943,0.008521751,0.00336477,0.03496074,0.003471304],"domain_scores_gemma":[0.9019436,0.01954944,0.005623565,0.005049449,0.06482494,0.003009141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002969833,0.0005520031,0.005501959,0.01480319,0.0004428875,0.001614277,0.002720321,0.005078077,0.02456469,0.08498446,0.3641338,0.4953074],"study_design_scores_gemma":[0.00004177758,0.0001408788,0.002124969,0.007278556,0.0001870945,0.0005795876,0.001070804,0.0004572476,0.006834502,0.01265433,0.9685302,0.0001000671],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.0126701,0.2913624,0.1662391,0.195694,0.01723308,0.01061543,0.0143404,0.003133691,0.2887118],"genre_scores_gemma":[0.09614396,0.3412591,0.2831101,0.1534399,0.004183486,0.01001965,0.03414675,0.001461857,0.07623534],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.09743899,"threshold_uncertainty_score":0.5153128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04821442180109668,"score_gpt":0.2957923922111775,"score_spread":0.2475779704100809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}