{"id":"W3037451731","doi":"10.1182/blood.2019002314","title":"The 14-3-3ζ–c-Src–integrin-β3 complex is vital for platelet activation","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Integrin; Proto-oncogene tyrosine-protein kinase Src; CD49c; Platelet activation; Platelet; Cell biology; Integrin, beta 6; Platelet adhesiveness; Signal transducing adaptor protein; Hemostasis; Chemistry; Collagen receptor; Clot retraction; Antithrombotic; Signal transduction; Biology; Receptor; Biochemistry; Medicine; Immunology; Thrombin; Internal medicine; Platelet aggregation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005801729,0.0001153591,0.00008544841,0.0000104844,0.0001853932,0.00005086117,0.0001949384,0.00009267824,0.00005416197],"category_scores_gemma":[0.0002344378,0.00009189586,0.0001095473,0.00005347068,0.00004206966,0.000005107295,0.00007752965,0.0001039513,0.00003599669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006916923,"about_ca_system_score_gemma":0.00003620291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000114096,"about_ca_topic_score_gemma":0.00001233616,"domain_scores_codex":[0.9993029,0.00002222136,0.0001525462,0.0002526919,0.00008689126,0.0001827908],"domain_scores_gemma":[0.9994937,0.0000414141,0.00007409372,0.0002272682,0.000100331,0.00006320325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001091843,0.00007594284,0.0001008414,0.00001098378,0.0001216616,6.611409e-7,0.00009929374,0.000004494878,0.9660041,0.0001714494,0.03136707,0.001934348],"study_design_scores_gemma":[0.0006489053,0.000214705,0.0002185581,0.000004203461,0.00001561311,0.000007373946,0.00007929919,0.00005409779,0.6574315,0.00008112433,0.3411554,0.00008920523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760274,0.000177237,0.009532868,0.01017602,0.0002165324,0.0008279583,0.0001730612,0.00004746162,0.002821431],"genre_scores_gemma":[0.9959523,0.00002725115,0.001041014,0.001505571,0.0005575957,0.0001148379,0.0001730651,0.00002475432,0.0006035833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3097883,"threshold_uncertainty_score":0.3747405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02605567643696568,"score_gpt":0.2698507558325884,"score_spread":0.2437950793956228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}