{"id":"W3037455779","doi":"10.1158/0008-5472.can-19-3822","title":"<i>NRAS</i> Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS–MAPK Pathway in Neuroblastoma","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Neuroblastoma; Neuroblastoma RAS viral oncogene homolog; Cancer research; Trametinib; MAPK/ERK pathway; Vemurafenib; KRAS; PTPN11; Anaplastic lymphoma kinase; Targeted therapy; Medicine; Crizotinib; Biology; Kinase; Cancer; Internal medicine; Cell culture; Lung cancer; Melanoma; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007867375,0.0001859837,0.0002755776,0.0002271279,0.0002443906,0.0000965067,0.0001494538,0.00005674416,0.00008426224],"category_scores_gemma":[0.001132966,0.000129029,0.00006874772,0.001186382,0.000183866,0.0001402879,0.0002554636,0.0007686535,0.0001271959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002551352,"about_ca_system_score_gemma":0.0004412719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005688709,"about_ca_topic_score_gemma":0.0004617447,"domain_scores_codex":[0.9964982,0.0007521961,0.0002485509,0.0005098177,0.001070986,0.0009202281],"domain_scores_gemma":[0.9980989,0.0006810313,0.0000371575,0.0002837486,0.0003740001,0.0005252152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001837184,0.0002956107,0.01618759,0.0001588175,0.00004800232,0.001125379,0.002733994,0.00004234464,0.9454793,0.00004738393,0.007377266,0.02466717],"study_design_scores_gemma":[0.005057973,0.003178779,0.07804429,0.0003147913,0.00001140286,0.0000274185,0.001222141,0.001100204,0.8811338,0.0001029596,0.02952037,0.0002858726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747447,0.000335487,0.00001842352,0.02305396,0.0001037479,0.001365405,0.00003930544,0.00006010046,0.0002788412],"genre_scores_gemma":[0.9971898,0.0001913966,0.00004387835,0.001698199,0.0003006721,0.000298263,0.00001241617,0.00004743457,0.0002180076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06434545,"threshold_uncertainty_score":0.5261649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06303302831595037,"score_gpt":0.3695045378502346,"score_spread":0.3064715095342843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}