{"id":"W3037461879","doi":"10.1371/journal.pcbi.1007892","title":"Implications of localized charge for human influenza A H1N1 hemagglutinin evolution: Insights from deep mutational scans","year":2020,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fogarty International Center; Science and Technology Directorate; Natural Sciences and Engineering Research Council of Canada; Bill and Melinda Gates Foundation; National Science Foundation; National Institutes of Health; James S. McDonnell Foundation; Medical Research Council; U.S. Department of Homeland Security","keywords":"Hemagglutinin (influenza); Avidity; Immune escape; Charge (physics); Immune system; Viral evolution; Biophysics; Surface charge; Influenza A virus; Biology; Evolutionary biology; Static electricity; Chemical physics; Chemistry; Antibody; Nanotechnology; Virus; Genetics; Physics; Gene; Materials science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006592159,0.0001747784,0.0004676765,0.0001912134,0.000226734,0.000007624933,0.000156141,0.0001189763,0.0002415796],"category_scores_gemma":[0.0006447844,0.0001589513,0.0001389228,0.0003878018,0.0003623403,0.00006094415,0.00009345834,0.0001588443,0.0000801781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001103848,"about_ca_system_score_gemma":0.0003043271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003827493,"about_ca_topic_score_gemma":0.00001290531,"domain_scores_codex":[0.9984253,0.00008920778,0.0005800113,0.0004028227,0.0002488886,0.0002537446],"domain_scores_gemma":[0.9977316,0.0007969233,0.0001987507,0.0001441626,0.0009581668,0.0001704041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.002092073,0.001097815,0.09285315,0.0004390798,0.002452853,0.000007708839,0.003687412,0.007159729,0.1663744,0.7196987,0.002809017,0.001328019],"study_design_scores_gemma":[0.02019831,0.003127084,0.3910059,0.0001845143,0.0005400295,0.00002017622,0.0004822488,0.16091,0.009697313,0.3940749,0.01889374,0.0008657138],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.817665,0.002269947,0.1629881,0.01057456,0.00007742954,0.002237406,0.001822839,0.0002046755,0.002159969],"genre_scores_gemma":[0.980058,0.000003533225,0.01412248,0.003636326,0.0003057156,0.0002858414,0.001553407,0.00002085154,0.00001384689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3256238,"threshold_uncertainty_score":0.6481848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1436535908808776,"score_gpt":0.397483108531006,"score_spread":0.2538295176501285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}