{"id":"W3037535166","doi":"10.1016/j.bcp.2020.114125","title":"The development of a targeted and more potent, anti-Inflammatory derivative of colchicine: Implications for gout","year":2020,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation CHU de Québec","keywords":"Colchicine; Gout; Pharmacology; Derivative (finance); Medicine; Chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001690745,0.000354883,0.0003750092,0.0002653216,0.0002362671,0.0004334212,0.0003907519,0.000533661,0.001846579],"category_scores_gemma":[0.0001501113,0.00009779538,0.000218514,0.0001964619,0.0003665883,0.0002939336,0.0001905626,0.001090894,0.0003806721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004858426,"about_ca_system_score_gemma":0.0005889438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001846248,"about_ca_topic_score_gemma":0.005559333,"domain_scores_codex":[0.9999392,0.00001444447,0.00000252935,0.00001056321,0.00001407162,0.00001918523],"domain_scores_gemma":[0.9999366,0.000008846176,0.00001163139,0.000003317506,0.00001513752,0.0000244336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001190776,0.0003677869,0.0004742701,0.0007559996,0.00003932871,0.000569318,0.00008113597,0.0006597235,0.9391335,0.003060847,0.002211203,0.05145617],"study_design_scores_gemma":[0.0009061873,0.01320934,0.007219342,0.0002263478,0.0002061492,0.003312717,0.0001958091,0.003080398,0.8537576,0.00140661,0.1163905,0.00008892026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7413282,0.1777298,0.03310497,0.009465179,0.001850938,0.0006907905,0.001883788,0.0006201313,0.0333262],"genre_scores_gemma":[0.9144457,0.05986835,0.01306885,0.002089788,0.0002721491,0.0001222277,0.0007629247,0.00004161177,0.009328345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001846579,"threshold_uncertainty_score":0.006177425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02755908669328241,"score_gpt":0.3253482303710909,"score_spread":0.2977891436778085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}